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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Radiolabeling procedure, quality control and stability of 99mTc-labeled chondroitin sulfate: a new approach of targeting osteoarthritis.

Chondroitin sulfate (CS) is an endogenous component of cartilage which could determine osteoarthritis after radiolabeling. Radiolabeling was performed by (99m)TcO(4)(-)/tin method. We found that pH is a limiting factor. At pH 6.2 in 0.05 M Na acetate buffer 32.8% colloid was formed, at pH 5.0 in 0.5M Na acetate, in our methodology only 4.7% colloid. The tracer was highly stable. We conclude that (99m)TcCS could be a promising imaging agent of osteoarthritis due to simple radiolabeling and high stability.[1]

References

  1. Radiolabeling procedure, quality control and stability of 99mTc-labeled chondroitin sulfate: a new approach of targeting osteoarthritis. Sobal, G., Menzel, E.J., Sinzinger, H. Appl. Radiat. Isot (2008) [Pubmed]
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