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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Enhancement of growth of virulent strains of Escherichia coli by interleukin-1.

Interleukin-1 ( IL-1) is a polypeptide cytokine that mediates many physiological responses to infection and inflammation and is a growth factor for certain mammalian cells. Virulent and avirulent clinical isolates of Escherichia coli were grown in culture media in the presence of human IL-1. IL-1 beta, but not tumor necrosis factor or IL-4, enhanced the growth of virulent, but not avirulent, E. coli. This enhancement was blocked by the IL-1 receptor antagonist (IL-1ra). Radiolabeled IL-1 bound to virulent but not avirulent E. coli in a specific and saturable fashion; IL-1ra inhibited this binding. Thus, human IL-1 may recognize a functional IL-1-like receptor structure on virulent E. coli and may be a virulence factor for bacterial pathogenicity.[1]


  1. Enhancement of growth of virulent strains of Escherichia coli by interleukin-1. Porat, R., Clark, B.D., Wolff, S.M., Dinarello, C.A. Science (1991) [Pubmed]
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