Gene Review:
IL4 - interleukin 4
Homo sapiens
Synonyms:
B-cell stimulatory factor 1, BCGF-1, BCGF1, BSF-1, BSF1, ...
Jacobson,
Bracher,
Corcos,
Salter,
Lee,
Mandrekar,
Chambry,
Guilbaud,
Gödekmerdan,
Cengiz Alpay,
Durham,
Chaouat,
Aral,
Jeammet,
Szabo,
Keles,
Yalçin,
Chanock,
Catalano,
Nouri-Aria,
Yoo,
Khan,
Kaygusuz,
Hamid,
Moussa,
Kalidağ,
Kodys,
Choi,
Wright,
Hjalmarsson,
Millward-Sadler,
Dolganiuc,
Loas,
Paterniti,
Varga,
Curt,
O'Brien,
Till,
Noble,
Walker,
- A chimeric protein comprised of IL-4 and Pseudomonas exotoxin is cytotoxic for activated human lymphocytes. Puri, R.K., Mehrotra, P.T., Leland, P., Kreitman, R.J., Siegel, J.P., Pastan, I. J. Immunol. (1994)
- A wide range of human cancers express interleukin 4 (IL4) receptors that can be targeted with chimeric toxin composed of IL4 and Pseudomonas exotoxin. Debinski, W., Puri, R.K., Kreitman, R.J., Pastan, I. J. Biol. Chem. (1993)
- Receptor for interleukin (IL) 13 does not interact with IL4 but receptor for IL4 interacts with IL13 on human glioma cells. Debinski, W., Miner, R., Leland, P., Obiri, N.I., Puri, R.K. J. Biol. Chem. (1996)
- A common haplotype of interleukin-4 gene IL4 is associated with severe respiratory syncytial virus disease in Korean children. Choi, E.H., Lee, H.J., Yoo, T., Chanock, S.J. J. Infect. Dis. (2002)
- Cytokine and chemokine gene polymorphisms among ethnically diverse North Americans with HIV-1 infection. Wang, C., Song, W., Lobashevsky, E., Wilson, C.M., Douglas, S.D., Mytilineos, J., Schoenbaum, E.E., Tang, J., Kaslow, R.A. J. Acquir. Immune Defic. Syndr. (2004)
- Correlation between serum levels of interleukin-4 and alexithymia scores in healthy female subjects: preliminary findings. Corcos, M., Guilbaud, O., Paterniti, S., Curt, F., Hjalmarsson, L., Moussa, M., Chambry, J., Loas, G., Chaouat, G., Jeammet, P. Psychoneuroendocrinology (2004)
- Reduced alloreactive T-cell activation after alcohol intake is due to impaired monocyte accessory cell function and correlates with elevated IL-10, IL-13, and decreased IFNgamma levels. Szabo, G., Mandrekar, P., Dolganiuc, A., Catalano, D., Kodys, K. Alcohol. Clin. Exp. Res. (2001)
- Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans. Dimitrov, S., Lange, T., Tieken, S., Fehm, H.L., Born, J. Brain Behav. Immun. (2004)
- Interleukin 4 and interleukin 10 levels are elevated in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Stoeck, K., Bodemer, M., Ciesielczyk, B., Meissner, B., Bartl, M., Heinemann, U., Zerr, I. Arch. Neurol. (2005)
- Fusion with the fused: a new role for interleukin-4 in the building of muscle. Chargé, S., Rudnicki, M.A. Cell (2003)
- Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface. Hage, T., Sebald, W., Reinemer, P. Cell (1999)
- Long-term clinical efficacy of grass-pollen immunotherapy. Durham, S.R., Walker, S.M., Varga, E.M., Jacobson, M.R., O'Brien, F., Noble, W., Till, S.J., Hamid, Q.A., Nouri-Aria, K.T. N. Engl. J. Med. (1999)
- The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. Hershey, G.K., Friedrich, M.F., Esswein, L.A., Thomas, M.L., Chatila, T.A. N. Engl. J. Med. (1997)
- Monocyte function in a severe combined immunodeficient patient with a donor splice site mutation in the Jak3 gene. Villa, A., Sironi, M., Macchi, P., Matteucci, C., Notarangelo, L.D., Vezzoni, P., Mantovani, A. Blood (1996)
- Functional role of interleukin-4 (IL-4) and IL-7 in the development of X-linked severe combined immunodeficiency. Kumaki, S., Ishii, N., Minegishi, M., Tsuchiya, S., Cosman, D., Sugamura, K., Konno, T. Blood (1999)
- Induction of 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene transcription in human breast cancer cell lines and in normal mammary epithelial cells by interleukin-4 and interleukin-13. Gingras, S., Moriggl, R., Groner, B., Simard, J. Mol. Endocrinol. (1999)
- Inhibition of toxic shock syndrome toxin-1-induced cytokine production and T cell activation by interleukin-10, interleukin-4, and dexamethasone. Krakauer, T. J. Infect. Dis. (1995)
- Serum interleukin 4 and interleukin 10 levels in patients with chronic hepatitis C virus infection. Reiser, M., Marousis, C.G., Nelson, D.R., Lauer, G., González-Peralta, R.P., Davis, G.L., Lau, J.Y. J. Hepatol. (1997)
- Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets. Casolaro, V., Georas, S.N., Song, Z., Zubkoff, I.D., Abdulkadir, S.A., Thanos, D., Ono, S.J. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Howard, T.D., Koppelman, G.H., Xu, J., Zheng, S.L., Postma, D.S., Meyers, D.A., Bleecker, E.R. Am. J. Hum. Genet. (2002)
- HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination. Wang, C., Tang, J., Song, W., Lobashevsky, E., Wilson, C.M., Kaslow, R.A. Hepatology (2004)
- Interleukin 4 regulates phosphorylation of serine 756 in the transactivation domain of Stat6. Roles for multiple phosphorylation sites and Stat6 function. Wang, Y., Malabarba, M.G., Nagy, Z.S., Kirken, R.A. J. Biol. Chem. (2004)
- A novel chimeric protein composed of interleukin 13 and Pseudomonas exotoxin is highly cytotoxic to human carcinoma cells expressing receptors for interleukin 13 and interleukin 4. Debinski, W., Obiri, N.I., Pastan, I., Puri, R.K. J. Biol. Chem. (1995)
- Induction of lymphokine-activated killer activity by interleukin 4 in human lymphocytes preactivated by interleukin 2 in vivo or in vitro. Higuchi, C.M., Thompson, J.A., Lindgren, C.G., Gillis, S., Widmer, M.B., Kern, D.E., Fefer, A. Cancer Res. (1989)
- JAK3 associates with the human interleukin 4 receptor and is tyrosine phosphorylated following receptor triggering. Rolling, C., Treton, D., Beckmann, P., Galanaud, P., Richard, Y. Oncogene (1995)
- Endogenous interleukin 6 plays an obligatory role in interleukin 4-dependent human IgE synthesis. Vercelli, D., Jabara, H.H., Arai, K., Yokota, T., Geha, R.S. Eur. J. Immunol. (1989)
- Transforming growth factor beta 1 and interleukin 4 induced alpha smooth muscle actin expression and myofibroblast-like differentiation in human synovial fibroblasts in vitro: modulation by basic fibroblast growth factor. Mattey, D.L., Dawes, P.T., Nixon, N.B., Slater, H. Ann. Rheum. Dis. (1997)
- The immune suppressive effect of dexamethasone in rheumatoid arthritis is accompanied by upregulation of interleukin 10 and by differential changes in interferon gamma and interleukin 4 production. Verhoef, C.M., van Roon, J.A., Vianen, M.E., Lafeber, F.P., Bijlsma, J.W. Ann. Rheum. Dis. (1999)
- Phorbol ester, prostaglandin E2, forskolin and okadaic acid differentially modulate interleukin-4-versus interleukin-2-dependent immunoglobulin induction in human cellular models, in contrast to other selected modifiers of cellular activation. Armerding, D., Hren, A. Int. Arch. Allergy Immunol. (1993)
- Roles for the interleukin-4 receptor and associated JAK/STAT proteins in human articular chondrocyte mechanotransduction. Millward-Sadler, S.J., Khan, N.S., Bracher, M.G., Wright, M.O., Salter, D.M. Osteoarthr. Cartil. (2006)
- Modulation of apoptosis with cytokines in B-cell chronic lymphocytic leukaemia. Mainou-Fowler, T., Prentice, A.G. Leuk. Lymphoma (1996)
- Monocyte cell surface glycosaminoglycans positively modulate IL-4-induced differentiation toward dendritic cells. den Dekker, E., Grefte, S., Huijs, T., ten Dam, G.B., Versteeg, E.M., van den Berk, L.C., Bladergroen, B.A., van Kuppevelt, T.H., Figdor, C.G., Torensma, R. J. Immunol. (2008)
- The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Lin, J.X., Migone, T.S., Tsang, M., Friedmann, M., Weatherbee, J.A., Zhou, L., Yamauchi, A., Bloom, E.T., Mietz, J., John, S. Immunity (1995)
- Interleukin-13 receptor alpha' but not alpha chain: a functional component of interleukin-4 receptors. Murata, T., Taguchi, J., Puri, R.K. Blood (1998)
- Interleukin-4 induces homotypic aggregation of human mast cells by promoting LFA-1/ICAM-1 adhesion molecules. Toru, H., Kinashi, T., Ra, C., Nonoyama, S., Yata, J., Nakahata, T. Blood (1997)
- Binding of IL-4 to the IL-13Ralpha(1)/IL-4Ralpha receptor complex leads to STAT3 phosphorylation but not to its nuclear translocation. Wery-Zennaro, S., Letourneur, M., David, M., Bertoglio, J., Pierre, J. FEBS Lett. (1999)
- Contribution of the interleukin 4 gene to susceptibility to subacute sclerosing panencephalitis. Inoue, T., Kira, R., Nakao, F., Ihara, K., Bassuny, W.M., Kusuhara, K., Nihei, K., Takeshita, K., Hara, T. Arch. Neurol. (2002)
- Comparison of IL-13- and IL-4-induced signaling in EBV-immortalized human B cells. Murata, T., Puri, R.K. Cell. Immunol. (1997)
- STAT6 mediates interleukin-4 growth inhibition in human breast cancer cells. Gooch, J.L., Christy, B., Yee, D. Neoplasia (2002)
- Expression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cells. Verbsky, J.W., Bach, E.A., Fang, Y.F., Yang, L., Randolph, D.A., Fields, L.E. J. Biol. Chem. (1996)
- Changes in the NMR-derived motional parameters of the insulin receptor substrate 1 phosphotyrosine binding domain upon binding to an interleukin 4 receptor phosphopeptide. Olejniczak, E.T., Zhou, M.M., Fesik, S.W. Biochemistry (1997)
- Acute allergen-induced airway remodeling in atopic asthma. Phipps, S., Benyahia, F., Ou, T.T., Barkans, J., Robinson, D.S., Kay, A.B. Am. J. Respir. Cell Mol. Biol. (2004)
- Phenotypic modulation of the stromal reticular network in normal and neoplastic lymph nodes: tissue transglutaminase reveals coordinate regulation of multiple cell types. Thomazy, V.A., Vega, F., Medeiros, L.J., Davies, P.J., Jones, D. Am. J. Pathol. (2003)
- Regulation of cytolytic cell populations from human peripheral blood by B cell stimulatory factor 1 (interleukin 4). Widmer, M.B., Acres, R.B., Sassenfeld, H.M., Grabstein, K.H. J. Exp. Med. (1987)
- Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production. D'Andrea, A., Ma, X., Aste-Amezaga, M., Paganin, C., Trinchieri, G. J. Exp. Med. (1995)
- Interleukin 8 (IL-8) selectively inhibits immunoglobulin E production induced by IL-4 in human B cells. Kimata, H., Yoshida, A., Ishioka, C., Lindley, I., Mikawa, H. J. Exp. Med. (1992)
- Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Punnonen, J., Aversa, G., Cocks, B.G., McKenzie, A.N., Menon, S., Zurawski, G., de Waal Malefyt, R., de Vries, J.E. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Interleukin 4 signals through two related pathways. Pernis, A., Witthuhn, B., Keegan, A.D., Nelms, K., Garfein, E., Ihle, J.N., Paul, W.E., Pierce, J.H., Rothman, P. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Russell, S.M., Tayebi, N., Nakajima, H., Riedy, M.C., Roberts, J.L., Aman, M.J., Migone, T.S., Noguchi, M., Markert, M.L., Buckley, R.H., O'Shea, J.J., Leonard, W.J. Science (1995)
- Interleukin 4 counteracts the interleukin 2-induced proliferation of monoclonal B cells. Karray, S., DeFrance, T., Merle-Béral, H., Banchereau, J., Debré, P., Galanaud, P. J. Exp. Med. (1988)
- Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma. Leung, D.Y., Martin, R.J., Szefler, S.J., Sher, E.R., Ying, S., Kay, A.B., Hamid, Q. J. Exp. Med. (1995)
- Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes. Smeland, E.B., Blomhoff, H.K., Funderud, S., Shalaby, M.R., Espevik, T. J. Exp. Med. (1989)
- Net inflammatory capacity of human septic shock plasma evaluated by a monocyte-based target cell assay: identification of interleukin-10 as a major functional deactivator of human monocytes. Brandtzaeg, P., Osnes, L., Ovstebø, R., Joø, G.B., Westvik, A.B., Kierulf, P. J. Exp. Med. (1996)
- Meniere's disease and allergy: allergens and cytokines. Keles, E., Gödekmerdan, A., Kalidağ, T., Kaygusuz, I., Yalçin, S., Cengiz Alpay, H., Aral, M. The Journal of laryngology and otology. (2004)
- Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease. Ghoreschi, K., Thomas, P., Breit, S., Dugas, M., Mailhammer, R., van Eden, W., van der Zee, R., Biedermann, T., Prinz, J., Mack, M., Mrowietz, U., Christophers, E., Schlöndorff, D., Plewig, G., Sander, C.A., Röcken, M. Nat. Med. (2003)