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Ziakas, A. et al.

Antonios Ziakas, Stavros Gavrilidis, Efthimia Souliou, George Giannoglou, Ioannis Stiliadis, Haralambos Karvounis, George Efthimiadis, Sotirios Mochlas, M. Arvanitidou Vayona, Apostolos Hatzitolios, Christos Savopoulos, Ifigenia Pidonia, George Parharidis,

Ceruloplasmin is a better predictor of the long-term prognosis compared with fibrinogen, CRP, and IL-6 in patients with severe unstable angina.

BACKGROUND: We investigated the time course and prognostic value of fibrinogen (Fib), C-reactive protein (CRP), interleukin-6 (IL-6), and ceruloplasmin (CP) in patients with severe unstable angina. METHODS: All 4 substances were measured on admission and after 6, 12, 24, 48, and 72 hours, and after 7 days and 6 months in 40 patients with Braunwald's classification class IIIB unstable angina. RESULTS: All recorded substances increased significantly; 15 patients had cardiovascular events during hospitalization and 11 patients during follow-up. The time course and the mean values of Fib, CRP, and IL-6 were similar in patients with and without complications both during hospitalization and follow-up. However, CP levels from 6 hours until 6 months were significantly higher in patients with complications during follow-up (P < .05). CONCLUSIONS: Fib, CRP, IL-6, and CP levels alter in patients with severe unstable angina. However, only CP levels were related to 12-month follow-up prognosis.[1]

References

Ceruloplasmin is a better predictor of the long-term prognosis compared with fibrinogen, CRP, and IL-6 in patients with severe unstable angina. Ziakas, A., Gavrilidis, S., Souliou, E., Giannoglou, G., Stiliadis, I., Karvounis, H., Efthimiadis, G., Mochlas, S., Vayona, M.A., Hatzitolios, A., Savopoulos, C., Pidonia, I., Parharidis, G. Angiology (2009) [Pubmed]

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