The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Angina, Unstable

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Angina, Unstable


Psychiatry related information on Angina, Unstable


High impact information on Angina, Unstable

  • CONCLUSIONS: In patients with unstable angina and myocardial infarction without ST-segment elevation who were treated with the glycoprotein IIb/IIIa inhibitor tirofiban, the use of an early invasive strategy significantly reduced the incidence of major cardiac events [7].
  • CONCLUSIONS: Pravastatin has a moderate effect in reducing the risk of stroke from any cause and the risk of nonhemorrhagic stroke in patients with previous myocardial infarction or unstable angina [8].
  • METHODS: Among 1265 patients with unstable angina who were enrolled in the c7E3 Fab Antiplatelet Therapy in Unstable Refractory Angina (CAPTURE) trial, serum samples drawn at the time of randomization to abciximab or placebo were available from 890 patients; we used these samples for the determination of troponin T and creatine kinase MB levels [9].
  • C-reactive protein and serum amyloid A protein in unstable angina [10].
  • The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina [2].

Chemical compound and disease context of Angina, Unstable


Biological context of Angina, Unstable


Anatomical context of Angina, Unstable

  • In patients with unstable angina, monocyte TF expression (both stimulated and unstimulated, assessed by biological activity and by antigen techniques) and fibrinogen levels were correlated with the time elapsed from the beginning of the most recent episode of pain (.61 < r < .72, .02 < P < .0001) [19].
  • Lymphocytes in patients with stable and unstable angina showed a similar percent expression of CD2/CD19 and CD3/HLA-DR antigens, with no difference between aortic and coronary sinus blood [20].
  • Intracellular neutrophil myeloperoxidase is reduced in unstable angina and acute myocardial infarction, but its reduction is not related to ischemia [21].
  • Seventy-two patients with stable or unstable angina treated since 1983 by multivessel-PTCA(MVP) were retrospectively compared with 44 similar patients that were suitable for MVP, but who had undergone bilateral mammary artery (BIMA) surgery (and additional vein grafts in 60.5% of the patients) since 1986 [22].
  • Stem cells in unstable angina: the dynamic duo [23].

Gene context of Angina, Unstable


Analytical, diagnostic and therapeutic context of Angina, Unstable


  1. Platelet activation in unstable coronary disease. Fitzgerald, D.J., Roy, L., Catella, F., FitzGerald, G.A. N. Engl. J. Med. (1986) [Pubmed]
  2. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. Liuzzo, G., Biasucci, L.M., Gallimore, J.R., Grillo, R.L., Rebuzzi, A.G., Pepys, M.B., Maseri, A. N. Engl. J. Med. (1994) [Pubmed]
  3. A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-Wave Coronary Events Study Group. Cohen, M., Demers, C., Gurfinkel, E.P., Turpie, A.G., Fromell, G.J., Goodman, S., Langer, A., Califf, R.M., Fox, K.A., Premmereur, J., Bigonzi, F. N. Engl. J. Med. (1997) [Pubmed]
  4. Silent ischemia in unstable angina: altered cardiac norepinephrine handling. Kleinman, B. Circulation (1994) [Pubmed]
  5. Alterations of coagulation and fibrinolytic and kallikrein-kinin systems in the acute and postacute phases in patients with unstable angina pectoris. Hoffmeister, H.M., Jur, M., Wendel, H.P., Heller, W., Seipel, L. Circulation (1995) [Pubmed]
  6. Reactivation of the coagulation system: rationale for long-term antithrombotic treatment. Kontny, F. Am. J. Cardiol. (1997) [Pubmed]
  7. Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban. Cannon, C.P., Weintraub, W.S., Demopoulos, L.A., Vicari, R., Frey, M.J., Lakkis, N., Neumann, F.J., Robertson, D.H., DeLucca, P.T., DiBattiste, P.M., Gibson, C.M., Braunwald, E. N. Engl. J. Med. (2001) [Pubmed]
  8. Pravastatin therapy and the risk of stroke. White, H.D., Simes, R.J., Anderson, N.E., Hankey, G.J., Watson, J.D., Hunt, D., Colquhoun, D.M., Glasziou, P., MacMahon, S., Kirby, A.C., West, M.J., Tonkin, A.M. N. Engl. J. Med. (2000) [Pubmed]
  9. Benefit of abciximab in patients with refractory unstable angina in relation to serum troponin T levels. c7E3 Fab Antiplatelet Therapy in Unstable Refractory Angina (CAPTURE) Study Investigators. Hamm, C.W., Heeschen, C., Goldmann, B., Vahanian, A., Adgey, J., Miguel, C.M., Rutsch, W., Berger, J., Kootstra, J., Simoons, M.L. N. Engl. J. Med. (1999) [Pubmed]
  10. C-reactive protein and serum amyloid A protein in unstable angina. Oltrona, L., Merlini, P.A., Pezzano, A. N. Engl. J. Med. (1995) [Pubmed]
  11. Reactivation of unstable angina after the discontinuation of heparin. Théroux, P., Waters, D., Lam, J., Juneau, M., McCans, J. N. Engl. J. Med. (1992) [Pubmed]
  12. The prognostic value of serum troponin T in unstable angina. Hamm, C.W., Ravkilde, J., Gerhardt, W., Jørgensen, P., Peheim, E., Ljungdahl, L., Goldmann, B., Katus, H.A. N. Engl. J. Med. (1992) [Pubmed]
  13. Prostacyclin for unstable angina. Szczeklik, A., Szczeklik, J., Nizankowski, R., Głuszko, P. N. Engl. J. Med. (1980) [Pubmed]
  14. Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitor. Xiao, Z., Théroux, P. Circulation (1998) [Pubmed]
  15. Differential suppression of thromboxane biosynthesis by indobufen and aspirin in patients with unstable angina. Cipollone, F., Patrignani, P., Greco, A., Panara, M.R., Padovano, R., Cuccurullo, F., Patrono, C., Rebuzzi, A.G., Liuzzo, G., Quaranta, G., Maseri, A. Circulation (1997) [Pubmed]
  16. Regional myocardial dysfunction in patients with angina at rest and response to isosorbide dinitrate assessed by phase analysis of radionuclide ventriculograms. Marzullo, P., Parodi, O., Schelbert, H.R., L'Abbate, A. J. Am. Coll. Cardiol. (1984) [Pubmed]
  17. Natural history of pure coronary artery spasm in patients treated medically. Bott-Silverman, C., Heupler, F.A. J. Am. Coll. Cardiol. (1983) [Pubmed]
  18. Platelet activation in unstable angina: role of thromboxane A2 and other mediators of vasoconstriction. Mehta, J.L. J. Am. Coll. Cardiol. (1990) [Pubmed]
  19. Evidence for time-dependent activation of monocytes in the systemic circulation in unstable angina but not in acute myocardial infarction or in stable angina. Jude, B., Agraou, B., McFadden, E.P., Susen, S., Bauters, C., Lepelley, P., Vanhaesbroucke, C., Devos, P., Cosson, A., Asseman, P. Circulation (1994) [Pubmed]
  20. Clinical and angiographic correlates of leukocyte activation in unstable angina. De Servi, S., Mazzone, A., Ricevuti, G., Mazzucchelli, I., Fossati, G., Gritti, D., Angoli, L., Specchia, G. J. Am. Coll. Cardiol. (1995) [Pubmed]
  21. Intracellular neutrophil myeloperoxidase is reduced in unstable angina and acute myocardial infarction, but its reduction is not related to ischemia. Biasucci, L.M., D'Onofrio, G., Liuzzo, G., Zini, G., Monaco, C., Caligiuri, G., Tommasi, M., Rebuzzi, A.G., Maseri, A. J. Am. Coll. Cardiol. (1996) [Pubmed]
  22. Bilateral mammary artery surgery or percutaneous transluminal coronary angioplasty for multivessel coronary artery disease? An analysis of effects and costs. Berreklouw, E., Hoogsteen, J., van Wandelen, R., Verkroost, M., Schonberger, J., Bavinck, H., Michels, R., Bonnier, H., el Deeb, M., el Gamal, M. Eur. Heart J. (1989) [Pubmed]
  23. Stem cells in unstable angina: the dynamic duo. Perera, D., Kanaganayagam, G., Marber, M. Eur. Heart J. (2004) [Pubmed]
  24. Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina. Liuzzo, G., Buffon, A., Biasucci, L.M., Gallimore, J.R., Caligiuri, G., Vitelli, A., Altamura, S., Ciliberto, G., Rebuzzi, A.G., Crea, F., Pepys, M.B., Maseri, A. Circulation (1998) [Pubmed]
  25. Elevated basic fibroblast growth factor in pericardial fluid of patients with unstable angina. Fujita, M., Ikemoto, M., Kishishita, M., Otani, H., Nohara, R., Tanaka, T., Tamaki, S., Yamazato, A., Sasayama, S. Circulation (1996) [Pubmed]
  26. Serum amyloid A predicts early mortality in acute coronary syndromes: A TIMI 11A substudy. Morrow, D.A., Rifai, N., Antman, E.M., Weiner, D.L., McCabe, C.H., Cannon, C.P., Braunwald, E. J. Am. Coll. Cardiol. (2000) [Pubmed]
  27. Interaction between chemokines and oxidative stress: possible pathogenic role in acute coronary syndromes. Aukrust, P., Berge, R.K., Ueland, T., Aaser, E., Damås, J.K., Wikeby, L., Brunsvig, A., Müller, F., Forfang, K., Frøland, S.S., Gullestad, L. J. Am. Coll. Cardiol. (2001) [Pubmed]
  28. The involvement of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in atherosclerosis. Michowitz, Y., Goldstein, E., Roth, A., Afek, A., Abashidze, A., Ben Gal, Y., Keren, G., George, J. J. Am. Coll. Cardiol. (2005) [Pubmed]
  29. Adding heparin to aspirin reduces the incidence of myocardial infarction and death in patients with unstable angina. A meta-analysis. Oler, A., Whooley, M.A., Oler, J., Grady, D. JAMA (1996) [Pubmed]
  30. Randomized trial of a GPIIb/IIIa platelet receptor blocker in refractory unstable angina. European Cooperative Study Group. Simoons, M.L., de Boer, M.J., van den Brand, M.J., van Miltenburg, A.J., Hoorntje, J.C., Heyndrickx, G.R., van der Wieken, L.R., de Bono, D., Rutsch, W., Schaible, T.F. Circulation (1994) [Pubmed]
  31. Effects of captopril on ischemic events after myocardial infarction. Results of the Survival and Ventricular Enlargement trial. SAVE Investigators. Rutherford, J.D., Pfeffer, M.A., Moyé, L.A., Davis, B.R., Flaker, G.C., Kowey, P.R., Lamas, G.A., Miller, H.S., Packer, M., Rouleau, J.L. Circulation (1994) [Pubmed]
  32. Long-term oral anticoagulant therapy in patients with unstable angina or suspected non-Q-wave myocardial infarction: organization to assess strategies for ischemic syndromes (OASIS) pilot study results. Anand, S.S., Yusuf, S., Pogue, J., Weitz, J.I., Flather, M. Circulation (1998) [Pubmed]
  33. Comparison of low-molecular-weight heparin with unfractionated heparin acutely and with placebo for 6 weeks in the management of unstable coronary artery disease. Fragmin in unstable coronary artery disease study (FRIC). Klein, W., Buchwald, A., Hillis, S.E., Monrad, S., Sanz, G., Turpie, A.G., van der Meer, J., Olaisson, E., Undeland, S., Ludwig, K. Circulation (1997) [Pubmed]
WikiGenes - Universities