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Schoppet, M. et al.

M. Schoppet, C.M. Shanahan,

Role for alkaline phosphatase as an inducer of vascular calcification in renal failure?

Vascular calcification is associated with increased cardiovascular morbidity and mortality. A number of calcification inhibitors have been defined recently, including inorganic pyrophosphate (PP(i)), an important physicochemical inhibitor of hydroxyapatite crystal growth. Increased hydrolysis of PP(i) by tissue-nonspecific alkaline phosphatase (TNAP) may occur in renal failure and act to enhance mineralization of vessels.[1]

References

Role for alkaline phosphatase as an inducer of vascular calcification in renal failure? Schoppet, M., Shanahan, C.M. Kidney Int. (2008) [Pubmed]

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