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Type 3 deiodinase in hypoxia: to cool or to kill?

Type 3 deiodinase (D3) inactivates thyroid hormones. Simonides et al. (2008) now report that hypoxia-induced D3 activation leads to reduction of 3,5,3'-triiodothyronine (T3) and oxygen consumption, suggesting that D3 activation is a component of cellular responses to hypoxia and supporting the idea of cell-specific regulation of thyroid hormone levels by deiodinases.[1]


  1. Type 3 deiodinase in hypoxia: to cool or to kill? Diano, S., Horvath, T.L. Cell Metab. (2008) [Pubmed]
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