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MeSH Review

Oxygen Consumption

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Disease relevance of Oxygen Consumption


Psychiatry related information on Oxygen Consumption


High impact information on Oxygen Consumption

  • Our analysis indicates that amino acids are the major fuel of liver, i.e., their oxidative conversion to glucose accounts for about one-half of the daily oxygen consumption of the liver, and no other fuel contributes nearly so importantly [10].
  • In the second part of the study, we used a graded exercise protocol in nine additional patients (group 2) to assess the effects of inhaled methoxamine on maximal exercise capacity and oxygen consumption [11].
  • As compared with fasting and the infusion of triglyceride with heparin, the glucose infusion lowered plasma levels of free fatty acids and ketones, reduced maximal work capacity by 60 to 70 percent, and lowered maximal oxygen consumption by 30 to 40 percent [12].
  • This assay measured arachidonic acid-induced oxygen consumption in platelets preincubated with aspirin to block cyclooxygenase activity [13].
  • Amiloride inhibited the ouabain-sensitive rate of oxygen consumption (QO2) of a suspension of rabbit intact proximal tubules in the presence of different concentrations of extracellular sodium [14].

Chemical compound and disease context of Oxygen Consumption


Biological context of Oxygen Consumption


Anatomical context of Oxygen Consumption


Associations of Oxygen Consumption with chemical compounds


Gene context of Oxygen Consumption

  • T3 increased metabolic rate [whole body oxygen consumption (MVO2)] in both WT and TR alpha-/- mice, but the effect in the TR alpha 1-/- mice at the highest dose was half that of the WT mice [35].
  • The inability to grow on raffinose is not caused by the cell iron content being too low to sustain respiratory metabolism, because the oxygen consumption of aft1 mutants showed that their respiratory activity is 2-fold higher than that of controls [36].
  • Cells that contain a functional FET3 gene product exhibited an iron-dependent non-mitochondrial increase in oxygen consumption [37].
  • Although food intake is not altered in FABP4-Wnt10b mice, oxygen consumption is decreased [38].
  • In PC12 cells, increased expression of the NAD-dependent deacetylase SIRT1 reduces cellular oxygen consumption by approximately 25% [39].

Analytical, diagnostic and therapeutic context of Oxygen Consumption


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  5. Deletion of the RIIbeta-subunit of protein kinase A decreases body weight and increases energy expenditure in the obese, leptin-deficient ob/ob mouse. Newhall, K.J., Cummings, D.E., Nolan, M.A., McKnight, G.S. Mol. Endocrinol. (2005) [Pubmed]
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  11. Improvement in exercise performance by inhalation of methoxamine in patients with impaired left ventricular function. Cabanes, L., Costes, F., Weber, S., Regnard, J., Benvenuti, C., Castaigne, A., Guerin, F., Lockhart, A. N. Engl. J. Med. (1992) [Pubmed]
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  13. Deficiency of platelet lipoxygenase activity in myeloproliferative disorders. Schafer, A.I. N. Engl. J. Med. (1982) [Pubmed]
  14. Amiloride directly inhibits the Na,K-ATPase activity of rabbit kidney proximal tubules. Soltoff, S.P., Mandel, L.J. Science (1983) [Pubmed]
  15. Stimulation of thermogenesis by carbohydrate overfeeding. Evidence against sympathetic nervous system mediation. Welle, S., Campbell, R.G. J. Clin. Invest. (1983) [Pubmed]
  16. Relation of myocardial oxygen consumption and function to high energy phosphate utilization during graded hypoxia and reoxygenation in sheep in vivo. Portman, M.A., Standaert, T.A., Ning, X.H. J. Clin. Invest. (1995) [Pubmed]
  17. The effect of coenzyme Q10 in patients with congestive heart failure. Khatta, M., Alexander, B.S., Krichten, C.M., Fisher, M.L., Freudenberger, R., Robinson, S.W., Gottlieb, S.S. Ann. Intern. Med. (2000) [Pubmed]
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  19. Failure of epinephrine to improve the balance between myocardial oxygen supply and demand during closed-chest resuscitation in dogs. Ditchey, R.V., Lindenfeld, J. Circulation (1988) [Pubmed]
  20. Cardiovascular responses of hyperactive children to methylphenidate. Ballard, J.E., Boileau, R.A., Sleator, E.K., Massey, B.H., Sprague, R.L. JAMA (1976) [Pubmed]
  21. Oxygen deprivation-induced injury to isolated rabbit kidney tubules. Weinberg, J.M. J. Clin. Invest. (1985) [Pubmed]
  22. Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice. Smart, J.L., Tolle, V., Low, M.J. J. Clin. Invest. (2006) [Pubmed]
  23. Amino acids and respiration. Weissman, C., Askanazi, J., Rosenbaum, S., Hyman, A.I., Milic-Emili, J., Kinney, J.M. Ann. Intern. Med. (1983) [Pubmed]
  24. Changes in energy balance and body composition at menopause: a controlled longitudinal study. Poehlman, E.T., Toth, M.J., Gardner, A.W. Ann. Intern. Med. (1995) [Pubmed]
  25. Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M.A., Chui, P.C., Leszyk, J., Straubhaar, J., Czech, M.P., Corvera, S. J. Clin. Invest. (2004) [Pubmed]
  26. The relationship of respiratory failure to the oxygen consumption of, lactate production by, and distribution of blood flow among respiratory muscles during increasing inspiratory resistance. Robertson, C.H., Foster, G.H., Johnson, R.L. J. Clin. Invest. (1977) [Pubmed]
  27. Respiratory chain defects in the mitochondria of cultured skin fibroblasts from three patients with lacticacidemia. Robinson, B.H., Ward, J., Goodyer, P., Baudet, A. J. Clin. Invest. (1986) [Pubmed]
  28. Hepatotoxicity of vitamin A and ethanol in the rat. Leo, M.A., Arai, M., Sato, M., Lieber, C.S. Gastroenterology (1982) [Pubmed]
  29. Substrate-level energy dependence of acid secretion in the isolated human gastric mucosa. Chacín, J., Prieto, A., Cárdenas, P. Gastroenterology (1985) [Pubmed]
  30. Starvation-induced decreased sensitivity of resting metabolic rate to triiodothyronine. Wimpfheimer, C., Saville, E., Voirol, M.J., Danforth, E., Burger, A.G. Science (1979) [Pubmed]
  31. The contrasting effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis. Marik, P.E., Mohedin, M. JAMA (1994) [Pubmed]
  32. Correlation of contractile dysfunction with oxidative energy production and tissue high energy phosphate stores during partial coronary flow disruption in rabbit heart. Marshall, R.C. J. Clin. Invest. (1988) [Pubmed]
  33. Prevention of bedrest-induced physical deconditioning by daily dobutamine infusions. Implications for drug-induced physical conditioning. Sullivan, M.J., Binkley, P.F., Unverferth, D.V., Ren, J.H., Boudoulas, H., Bashore, T.M., Merola, A.J., Leier, C.V. J. Clin. Invest. (1985) [Pubmed]
  34. The distribution of blood flow, oxygen consumption, and work output among the respiratory muscles during unobstructed hyperventilation. Robertson, C.H., Pagel, M.A., Johnson, R.L. J. Clin. Invest. (1977) [Pubmed]
  35. Selective thyroid hormone receptor-beta activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability. Grover, G.J., Mellström, K., Ye, L., Malm, J., Li, Y.L., Bladh, L.G., Sleph, P.G., Smith, M.A., George, R., Vennström, B., Mookhtiar, K., Horvath, R., Speelman, J., Egan, D., Baxter, J.D. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  36. Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast. Blaiseau, P.L., Lesuisse, E., Camadro, J.M. J. Biol. Chem. (2001) [Pubmed]
  37. The FET3 gene product required for high affinity iron transport in yeast is a cell surface ferroxidase. De Silva, D.M., Askwith, C.C., Eide, D., Kaplan, J. J. Biol. Chem. (1995) [Pubmed]
  38. Wnt10b inhibits development of white and brown adipose tissues. Longo, K.A., Wright, W.S., Kang, S., Gerin, I., Chiang, S.H., Lucas, P.C., Opp, M.R., MacDougald, O.A. J. Biol. Chem. (2004) [Pubmed]
  39. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. Nemoto, S., Fergusson, M.M., Finkel, T. J. Biol. Chem. (2005) [Pubmed]
  40. Effect of vasoactive agents on intestinal oxygen consumption and blood flow in dogs. Pawlik, W., Shepherd, A.P., Jacobson, E.D. J. Clin. Invest. (1975) [Pubmed]
  41. Role of changes in insulin and glucagon in glucose homeostasis in exercise. Wolfe, R.R., Nadel, E.R., Shaw, J.H., Stephenson, L.A., Wolfe, M.H. J. Clin. Invest. (1986) [Pubmed]
  42. Myocardial free-radical injury after cardioplegia. Weisel, R.D., Mickle, D.A., Finkle, C.D., Tumiati, L.C., Madonik, M.M., Ivanov, J., Burton, G.W., Ingold, K.U. Circulation (1989) [Pubmed]
  43. Steroid-induced myocardial preservation is associated with decreased cell membrane microviscosity. Engelman, R.M., Prasad, M.R., Rousou, J.A., Breyer, R.H., Bagchi, M., Das, D.K. Circulation (1989) [Pubmed]
  44. Contrasting effects of nifedipine and adenosine on regional myocardial flow distribution and metabolism distal to a severe coronary arterial stenosis: observations in sedated, closed-chest, domestic swine. Gewirtz, H., Gross, S.L., Williams, D.O., Most, A.S. Circulation (1984) [Pubmed]
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