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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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High impulsivity predicts the switch to compulsive cocaine-taking.

Both impulsivity and novelty-seeking have been suggested to be behavioral markers of the propensity to take addictive drugs. However, their relevance for the vulnerability to compulsively seek and take drugs, which is a hallmark feature of addiction, is unknown. We report here that, whereas high reactivity to novelty predicts the propensity to initiate cocaine self-administration, high impulsivity predicts the development of addiction-like behavior in rats, including persistent or compulsive drug-taking in the face of aversive outcomes. This study shows experimental evidence that a shift from impulsivity to compulsivity occurs during the development of addictive behavior, which provides insights into the genesis and neural mechanisms of drug addiction.[1]

References

  1. High impulsivity predicts the switch to compulsive cocaine-taking. Belin, D., Mar, A.C., Dalley, J.W., Robbins, T.W., Everitt, B.J. Science (2008) [Pubmed]
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