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MeSH Review

Behavior, Addictive

 
 
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Disease relevance of Behavior, Addictive

 

Psychiatry related information on Behavior, Addictive

 

High impact information on Behavior, Addictive

  • These observations suggest that the CB1 receptor is involved in the motivational properties of opiates and in the development of physical dependence and extend the concept of an interconnected role of CB1 and opiate receptors in the brain areas mediating addictive behavior [7].
  • The mesolimbic dopamine system and cAMP-dependent/protein kinase A (PKA) pathways are strongly implicated in addictive behaviors [8].
  • This SNP, which converts a conserved proline residue in FAAH to threonine (P129T), suggests a potential role for the FAAH-endocannabinoid system in regulating addictive behavior [9].
  • These results support a role for genetic variants of the DRD1 gene in some addictive behaviors, and an interaction of genetic variants at the DRD1 and DRD2 genes [10].
  • As stimulus-reward learning is likely relevant to addictive behavior (i.e., augmented conditioned reward and stimulus control of behavior), we have investigated whether prior repeated administration of psychomotor stimulant drugs (of abuse, including cocaine, d-amphetamine, or MDMA, would affect the acquisition of Pavlovian approach behavior [11].
 

Chemical compound and disease context of Behavior, Addictive

 

Biological context of Behavior, Addictive

 

Gene context of Behavior, Addictive

References

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  12. Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1 dopamine receptor. Moratalla, R., Xu, M., Tonegawa, S., Graybiel, A.M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
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  14. Voluntary wheel running modulates glutamate receptor subunit gene expression and stress hormone release in Lewis rats. Makatsori, A., Duncko, R., Schwendt, M., Moncek, F., Johansson, B.B., Jezova, D. Psychoneuroendocrinology (2003) [Pubmed]
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  20. High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users. Kim, D.J., Roh, S., Kim, Y., Yoon, S.J., Lee, H.K., Han, C.S., Kim, Y.K. Neurosci. Lett. (2005) [Pubmed]
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