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MeSH Review

Behavior, Addictive

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Disease relevance of Behavior, Addictive


Psychiatry related information on Behavior, Addictive


High impact information on Behavior, Addictive

  • These observations suggest that the CB1 receptor is involved in the motivational properties of opiates and in the development of physical dependence and extend the concept of an interconnected role of CB1 and opiate receptors in the brain areas mediating addictive behavior [7].
  • The mesolimbic dopamine system and cAMP-dependent/protein kinase A (PKA) pathways are strongly implicated in addictive behaviors [8].
  • This SNP, which converts a conserved proline residue in FAAH to threonine (P129T), suggests a potential role for the FAAH-endocannabinoid system in regulating addictive behavior [9].
  • These results support a role for genetic variants of the DRD1 gene in some addictive behaviors, and an interaction of genetic variants at the DRD1 and DRD2 genes [10].
  • As stimulus-reward learning is likely relevant to addictive behavior (i.e., augmented conditioned reward and stimulus control of behavior), we have investigated whether prior repeated administration of psychomotor stimulant drugs (of abuse, including cocaine, d-amphetamine, or MDMA, would affect the acquisition of Pavlovian approach behavior [11].

Chemical compound and disease context of Behavior, Addictive


Biological context of Behavior, Addictive


Gene context of Behavior, Addictive


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  10. Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors. Comings, D.E., Gade, R., Wu, S., Chiu, C., Dietz, G., Muhleman, D., Saucier, G., Ferry, L., Rosenthal, R.J., Lesieur, H.R., Rugle, L.J., MacMurray, P. Mol. Psychiatry (1997) [Pubmed]
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  12. Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1 dopamine receptor. Moratalla, R., Xu, M., Tonegawa, S., Graybiel, A.M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  13. A subset of ventral tegmental area neurons is inhibited by dopamine, 5-hydroxytryptamine and opioids. Cameron, D.L., Wessendorf, M.W., Williams, J.T. Neuroscience (1997) [Pubmed]
  14. Voluntary wheel running modulates glutamate receptor subunit gene expression and stress hormone release in Lewis rats. Makatsori, A., Duncko, R., Schwendt, M., Moncek, F., Johansson, B.B., Jezova, D. Psychoneuroendocrinology (2003) [Pubmed]
  15. Ethanol stimulates cAMP-responsive element (CRE)-mediated transcription via CRE-binding protein and cAMP-dependent protein kinase. Asher, O., Cunningham, T.D., Yao, L., Gordon, A.S., Diamond, I. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  16. Reduction of withdrawal signs after chronic nicotine exposure of alpha-calcitonin gene-related peptide knock-out mice. Salmon, A.M., Evrard, A., Damaj, I., Changeux, J.P. Neurosci. Lett. (2004) [Pubmed]
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  19. Studies of the 48 bp repeat polymorphism of the DRD4 gene in impulsive, compulsive, addictive behaviors: Tourette syndrome, ADHD, pathological gambling, and substance abuse. Comings, D.E., Gonzalez, N., Wu, S., Gade, R., Muhleman, D., Saucier, G., Johnson, P., Verde, R., Rosenthal, R.J., Lesieur, H.R., Rugle, L.J., Miller, W.B., MacMurray, J.P. Am. J. Med. Genet. (1999) [Pubmed]
  20. High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users. Kim, D.J., Roh, S., Kim, Y., Yoon, S.J., Lee, H.K., Han, C.S., Kim, Y.K. Neurosci. Lett. (2005) [Pubmed]
  21. Smoking status and the human dopamine transporter variable number of tandem repeats (VNTR) polymorphism: failure to replicate and finding that never-smokers may be different. Vandenbergh, D.J., Bennett, C.J., Grant, M.D., Strasser, A.A., O'Connor, R., Stauffer, R.L., Vogler, G.P., Kozlowski, L.T. Nicotine Tob. Res. (2002) [Pubmed]
  22. Partial deletion of the cAMP response element-binding protein gene promotes alcohol-drinking behaviors. Pandey, S.C., Roy, A., Zhang, H., Xu, T. J. Neurosci. (2004) [Pubmed]
  23. Behavioral and neurochemical vulnerability during adolescence in mice: studies with nicotine. Adriani, W., Granstrem, O., Macri, S., Izykenova, G., Dambinova, S., Laviola, G. Neuropsychopharmacology (2004) [Pubmed]
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