High impact information on COCAINE HYDROCHLORIDE

• New Zealand rabbits received multiple i.c.v. doses of cocaine, pseudococaine, lidocaine or desipramine while recording blood pressure and heart rate [1].
• Lidocaine and pseudococaine produced dose-dependent increases in blood pressure while desipramine produced decreases in heart rate and mean arterial pressure [1].
• The biosensor discriminated by 833-fold between cocaine and its stereoisomer pseudococaine [2].
• Cocaine and pseudococaine: comparative effects on electrical after-discharge in the limbic system of cats [3].

Psychiatry related information on COCAINE HYDROCHLORIDE

• We show that this disconnection selectively decreased drug-seeking behavior in rats extensively trained under a second-order schedule of cocaine reinforcement [4].

Associations of COCAINE HYDROCHLORIDE with other chemical compounds

• Subchronic treatment with WIN 55,212-2 in rats without a history of cocaine self-administration did not affect anxiety levels [5].
• Significant cocaine dose-related sex differences were observed, but no consistent changes in cocaine self-administration as a function of menstrual cycle phase, or levels of estradiol and progesterone, were detected in female cynomolgus monkeys [6].
• Blunted dopamine transmission in the ventral striatum and anterior caudate was predictive of the choice for cocaine over money [7].
• Results confirm our previous findings on the role of central amygdala glutamate in the incubation of cocaine craving and together with previous reports suggest that mGluR(2/3) agonists should be considered in the treatment of drug relapse [8].
• No age-related difference was observed in acquisition of cocaine self-administration, or in basal or cocaine-stimulated nucleus accumbens dopamine [9].
• Rats pre-exposed to cocaine plus prazosin did not show enhanced cocaine self-administration [10].
• We, therefore, evaluated the ability of SR 48692, administered after a cocaine regimen, to interfere with the expression of locomotor sensitization and conditioned place preference (CPP) in rats [11].
• Taken together, these data suggest that over the dose range studied, estradiol administration does not consistently alter the abuse-related effects of cocaine in female rhesus monkeys [12].
• Our data demonstrate the molecular basis for the competitive inhibition of dopamine transport by cocaine [13].
• Intra-NAc application of Ro 60-0175 dose-dependently excited (0.1 microM) and inhibited (1 microM) cocaine-induced DA outflow [14].
• The higher level of SERT availability in cocaine-experienced monkeys may lead to a reduced inhibitory tone of 5-HT on the DA system, which may explain, in part, differences in the abuse liability between cocaine and MDMA [15].
• The conditioned activation of the dopamine system by cocaine-predictive cues offers a new target for potential addiction therapies [16].

Gene context of COCAINE HYDROCHLORIDE

• We have analyzed the acute response to cocaine in animals deleted for the expression of DA D2 receptors (D2R), an inhibitor of DA signaling [17].
• These results demonstrate profound and persistent effects of NAc Cdk5 inhibition on locomotor sensitization and incentive-motivational processes and provide direct evidence for a role for striatal Cdk5-induced alterations in the brain's long-term adaptations to cocaine [18].
• Selective activation of ERbeta with DPN also increased cocaine-induced reinstatement responding, whereas selective activation of ERalpha with PPT did not affect cocaine-seeking behavior [19].

Analytical, diagnostic and therapeutic context of COCAINE HYDROCHLORIDE

• Pseudococaine produced high-voltage slow waves (HVSWs) in the EEG associated with behavioral depression [3].
• During this period, animals were randomized to receive either cocaine-hydrochloride (0.25 mg/kg) intravenously (n = 17) twice daily; or an equivalent volume of 0.9% physiologic saline, control group (n = 16) [20].
• The convulsant effects of cocaine and its C2-epimer, pseudococaine on EEG, respiration, heart rate and behavior were studied in the rhesus monkeys with electrodes implanted in the brain [21].

References