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Chemical Compound Review

cocaine     methyl8-methyl-3- (phenylcarbonyloxy)-8...

Synonyms: Allococaine, Pseudococaine, CHEMBL32363, SureCN21931, AGN-PC-00G043, ...
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High impact information on COCAINE HYDROCHLORIDE


Psychiatry related information on COCAINE HYDROCHLORIDE

  • We show that this disconnection selectively decreased drug-seeking behavior in rats extensively trained under a second-order schedule of cocaine reinforcement [4].

Associations of COCAINE HYDROCHLORIDE with other chemical compounds



  • We have analyzed the acute response to cocaine in animals deleted for the expression of DA D2 receptors (D2R), an inhibitor of DA signaling [17].
  • These results demonstrate profound and persistent effects of NAc Cdk5 inhibition on locomotor sensitization and incentive-motivational processes and provide direct evidence for a role for striatal Cdk5-induced alterations in the brain's long-term adaptations to cocaine [18].
  • Selective activation of ERbeta with DPN also increased cocaine-induced reinstatement responding, whereas selective activation of ERalpha with PPT did not affect cocaine-seeking behavior [19].

Analytical, diagnostic and therapeutic context of COCAINE HYDROCHLORIDE


  1. Centrally mediated hemodynamic effects of cocaine in rabbits: the role of local anesthetic actions and biogenic amine re-uptake blockage. Bernards, C.M. Eur. J. Pharmacol. (1996) [Pubmed]
  2. A fiber-optic cocaine biosensor. Devine, P.J., Anis, N.A., Wright, J., Kim, S., Eldefrawi, A.T., Eldefrawi, M.E. Anal. Biochem. (1995) [Pubmed]
  3. Cocaine and pseudococaine: comparative effects on electrical after-discharge in the limbic system of cats. Matsuzaki, M., Misra, A.L. Brain Res. Bull. (1978) [Pubmed]
  4. Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. Belin, D., Everitt, B.J. Neuron (2008) [Pubmed]
  5. Subchronic cannabinoid agonist (WIN 55,212-2) treatment during cocaine abstinence alters subsequent cocaine seeking behavior. González-Cuevas, G., Aujla, H., Martin-Fardon, R., López-Moreno, J.A., Navarro, M., Weiss, F. Neuropsychopharmacology (2007) [Pubmed]
  6. Sex and menstrual cycle effects on progressive ratio measures of cocaine self-administration in cynomolgus monkeys. Mello, N.K., Knudson, I.M., Mendelson, J.H. Neuropsychopharmacology (2007) [Pubmed]
  7. Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine. Martinez, D., Narendran, R., Foltin, R.W., Slifstein, M., Hwang, D.R., Broft, A., Huang, Y., Cooper, T.B., Fischman, M.W., Kleber, H.D., Laruelle, M. Am. J. Psychiatry (2007) [Pubmed]
  8. Systemic and central amygdala injections of the mGluR(2/3) agonist LY379268 attenuate the expression of incubation of cocaine craving. Lu, L., Uejima, J.L., Gray, S.M., Bossert, J.M., Shaham, Y. Biol. Psychiatry (2007) [Pubmed]
  9. Behavioral and neurochemical responses to cocaine in periadolescent and adult rats. Frantz, K.J., O'Dell, L.E., Parsons, L.H. Neuropsychopharmacology (2007) [Pubmed]
  10. Previous exposure to cocaine enhances cocaine self-administration in an alpha 1-adrenergic receptor dependent manner. Zhang, X.Y., Kosten, T.A. Neuropsychopharmacology (2007) [Pubmed]
  11. Neurotensin receptor antagonist administered during cocaine withdrawal decreases locomotor sensitization and conditioned place preference. Felszeghy, K., Espinosa, J.M., Scarna, H., Bérod, A., Rostène, W., Pélaprat, D. Neuropsychopharmacology (2007) [Pubmed]
  12. Effects of estradiol on cocaine self-administration and cocaine discrimination by female rhesus monkeys. Mello, N.K., Negus, S.S., Knudson, I.M., Kelly, M., Mendelson, J.H. Neuropsychopharmacology (2008) [Pubmed]
  13. The binding sites for cocaine and dopamine in the dopamine transporter overlap. Beuming, T., Kniazeff, J., Bergmann, M.L., Shi, L., Gracia, L., Raniszewska, K., Newman, A.H., Javitch, J.A., Weinstein, H., Gether, U., Loland, C.J. Nat. Neurosci. (2008) [Pubmed]
  14. Differential regulation of the mesoaccumbens dopamine circuit by serotonin2C receptors in the ventral tegmental area and the nucleus accumbens: an in vivo microdialysis study with cocaine. Navailles, S., Moison, D., Cunningham, K.A., Spampinato, U. Neuropsychopharmacology (2008) [Pubmed]
  15. Effects of cocaine and MDMA self-administration on serotonin transporter availability in monkeys. Banks, M.L., Czoty, P.W., Gage, H.D., Bounds, M.C., Garg, P.K., Garg, S., Nader, M.A. Neuropsychopharmacology (2008) [Pubmed]
  16. Differentiating the rapid actions of cocaine. Wise, R.A., Kiyatkin, E.A. Nat. Rev. Neurosci. (2011) [Pubmed]
  17. Absence of dopamine D2 receptors unmasks an inhibitory control over the brain circuitries activated by cocaine. Welter, M., Vallone, D., Samad, T.A., Meziane, H., Usiello, A., Borrelli, E. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  18. Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine. Taylor, J.R., Lynch, W.J., Sanchez, H., Olausson, P., Nestler, E.J., Bibb, J.A. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  19. Estrogen receptor beta, but not alpha, mediates estrogen's effect on cocaine-induced reinstatement of extinguished cocaine-seeking behavior in ovariectomized female rats. Larson, E.B., Carroll, M.E. Neuropsychopharmacology (2007) [Pubmed]
  20. Increased prevalence of aortic fatty streaks in cholesterol-fed rabbits administered intravenous cocaine: the role of vascular endothelium. Kolodgie, F.D., Wilson, P.S., Cornhill, J.F., Herderick, E.E., Mergner, W.J., Virmani, R. Toxicologic pathology. (1993) [Pubmed]
  21. Comparison of the convulsant effects of cocaine and pseudococaine in the rhesus monkey. Matsuzaki, M., Misra, A.L. Brain Res. Bull. (1977) [Pubmed]
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