The effects of high dietary concentrations of sodium saccharin on in vivo metabolism of xenobiotics in rats.
The effect of feeding a diet containing 7.5% sodium saccharin on the conjugation of [14C]phenol has been studied during neonatal development in male and female rats using a two-generation protocol. Decreased formation of phenol sulphate was observed in the F1 saccharin-treated rats from 4 wk of age and this was compensated for by an increase in the formation of quinol glucuronide. This shift in the conjugation pattern of [14C]phenol, with an increase in oxidation, was not sex specific. The daily excretion of indican was significantly increased from 5 wk of age. Feeding a diet containing 7.5% sodium saccharin did not affect in vitro activities of the enzymes involved in the conjugation reactions, that is, aryl sulphotransferase and uridine-5'-diphosphate glucuronyltransferase. The incorporation of 5% cysteine into the diet of saccharin-treated rats for 1 wk prevented the change in conjugation of [14C]phenol observed in the saccharin-treated animals. Absorption of sodium [35S]sulphate from the gastro-intestinal tract was not appreciably affected by a high dietary concentration of sodium saccharin. A high dietary concentration of saccharin affected the conjugation of 3-hydroxyanthranilic acid during neonatal development, possibly as a result of sulphate depletion.[1]References
- The effects of high dietary concentrations of sodium saccharin on in vivo metabolism of xenobiotics in rats. Heaton, G.D., Renwick, A.G. Food Chem. Toxicol. (1991) [Pubmed]
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