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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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CFTR polymorphisms in patients with alcoholic chronic pancreatitis.

INTRODUCTION: Pancreas susceptibility to alcohol is variable and only 5-10% of chronic alcohol abusers develop chronic pancreatitis; the role of genetic factors in this process is unknown. The CFTR gene encodes a protein that acts on epithelial cells and plays a key role in normal exocrine pancreatic function. METHODS: This study investigated the frequency of polymorphisms in intron 8 of the CFTR gene in patients with alcoholic chronic pancreatitis. Three groups of patients were studied: group A - 68 adult alcoholics with a diagnosis of chronic pancreatitis; group B - 68 adult alcoholics without pancreatic disease or liver cirrhosis and group C - 104 healthy nonalcoholic adults. RESULTS: T5/T7 genotype was more frequent in group A (11.8%) than in group B (2.9%) (p = 0.0481), and there was no statistical difference when groups A and C (5.8%) were compared (p = 0.1317). The haplotype combination (TG)10-T7/(TG)11-T7 was more frequent in groups B (23.5%) and C (20.2%) than in group A (7.3%) (p = 0.0080 and 0.0162). CONCLUSION: There are differences when these three groups are compared and individuals with T5/T7 genotype might have a greater risk of developing chronic pancreatitis when they become chronic alcoholics.[1]

References

  1. CFTR polymorphisms in patients with alcoholic chronic pancreatitis. da Costa, M.Z., Guarita, D.R., Ono-Nita, S.K., Nogueira, J.A., Nita, M.E., Paranaguá-Vezozzo, D.C., de Souza, M.T., do Carmo, E.P., Teixeira, A.C., Carrilho, F.J. Pancreatology (2009) [Pubmed]
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