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MeSH Review

Pancreatitis, Chronic

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Disease relevance of Pancreatitis, Chronic


Psychiatry related information on Pancreatitis, Chronic


High impact information on Pancreatitis, Chronic


Chemical compound and disease context of Pancreatitis, Chronic


Biological context of Pancreatitis, Chronic


Anatomical context of Pancreatitis, Chronic


Gene context of Pancreatitis, Chronic

  • METHODS: We tested 39 patients with idiopathic chronic pancreatitis (mean age at diagnosis, 33 years) for common mutations of CFTR and of genes encoding a trypsin inhibitor (PSTI) and trypsinogen (PRSS1) [4].
  • CCK1 receptor proteins were found occasionally in small-sized pancreatic nerves, whereas acini expressed a low density of CCK2 receptors in a few cases of chronic pancreatitis [29].
  • CONCLUSIONS: The observed differential expression of distinct chemokine genes in pancreatic parenchyma and infiltrates from patients with chronic pancreatitis strongly suggests an involvement of distinct chemokines in the initiation and perpetuation of disease [30].
  • Transgenic mice overexpressing TGF-alpha develop tissue changes in the pancrease resembling changes found in chronic pancreatitis [31].
  • In this study we investigated the potential role of aFGF and bFGF in chronic pancreatitis (CP), a fibrotic condition associated with acinar cell dedifferentiation and atrophy, and fibroblastic proliferation [32].

Analytical, diagnostic and therapeutic context of Pancreatitis, Chronic


  1. Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases. Orelle, B., Keim, V., Masciotra, L., Dagorn, J.C., Iovanna, J.L. J. Clin. Invest. (1992) [Pubmed]
  2. Immunochemical characterization and quantitative distribution of pancreatic stone protein in sera and pancreatic secretions in pancreatic disorders. Schmiegel, W., Burchert, M., Kalthoff, H., Roeder, C., Bützow, G., Grimm, H., Kremer, B., Soehendra, N., Schreiber, H.W., Thiele, H.G. Gastroenterology (1990) [Pubmed]
  3. Localization of transforming growth factor beta 1 and its latent binding protein in human chronic pancreatitis. van Laethem, J.L., Deviere, J., Resibois, A., Rickaert, F., Vertongen, P., Ohtani, H., Cremer, M., Miyazono, K., Robberecht, P. Gastroenterology (1995) [Pubmed]
  4. Cystic fibrosis gene mutations and pancreatitis risk: relation to epithelial ion transport and trypsin inhibitor gene mutations. Noone, P.G., Zhou, Z., Silverman, L.M., Jowell, P.S., Knowles, M.R., Cohn, J.A. Gastroenterology (2001) [Pubmed]
  5. Serum antibodies to carbonic anhydrase I and II in patients with idiopathic chronic pancreatitis and Sjögren's syndrome. Kino-Ohsaki, J., Nishimori, I., Morita, M., Okazaki, K., Yamamoto, Y., Onishi, S., Hollingsworth, M.A. Gastroenterology (1996) [Pubmed]
  6. Quantitative proteomics analysis reveals that proteins differentially expressed in chronic pancreatitis are also frequently involved in pancreatic cancer. Chen, R., Brentnall, T.A., Pan, S., Cooke, K., Moyes, K.W., Lane, Z., Crispin, D.A., Goodlett, D.R., Aebersold, R., Bronner, M.P. Mol. Cell Proteomics (2007) [Pubmed]
  7. Evidence for modulation of motilin secretion by pancreatico-biliary juice in health and in chronic pancreatitis. Owyang, C., Funakoshi, A., Vinik, A.I. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  8. Racial factors and the risk of chronic pancreatitis. Lowenfels, A.B., Maisonneuve, P., Grover, H., Gerber, E., Korsten, M.A., Antunes, M.T., Marques, A., Pitchumoni, C.S. Am. J. Gastroenterol. (1999) [Pubmed]
  9. Oxidative stress in blood of patients with alcohol-related pancreatitis. Szuster-Ciesielska, A., Daniluk, J., Kandefer-Szerszeń, M. Pancreas (2001) [Pubmed]
  10. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Witt, H., Luck, W., Hennies, H.C., Classen, M., Kage, A., Lass, U., Landt, O., Becker, M. Nat. Genet. (2000) [Pubmed]
  11. A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM Study Group. Imagawa, A., Hanafusa, T., Miyagawa, J., Matsuzawa, Y. N. Engl. J. Med. (2000) [Pubmed]
  12. Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis. Cohn, J.A., Friedman, K.J., Noone, P.G., Knowles, M.R., Silverman, L.M., Jowell, P.S. N. Engl. J. Med. (1998) [Pubmed]
  13. Cimetidine plus propantheline for chronic pancreatitis. Weinstein, G.S., Dupont, P.J. N. Engl. J. Med. (1978) [Pubmed]
  14. Treatment of pancreatic pseudocysts with octreotide. Gullo, L., Barbara, L. Lancet (1991) [Pubmed]
  15. Diabetic retinopathy in chronic pancreatitis. Gullo, L., Parenti, M., Monti, L., Pezzilli, R., Barbara, L. Gastroenterology (1990) [Pubmed]
  16. Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats. Kuno, A., Yamada, T., Masuda, K., Ogawa, K., Sogawa, M., Nakamura, S., Nakazawa, T., Ohara, H., Nomura, T., Joh, T., Shirai, T., Itoh, M. Gastroenterology (2003) [Pubmed]
  17. Pancreatic blood flow in cats with chronic pancreatitis. Reber, H.A., Karanjia, N.D., Alvarez, C., Widdison, A.L., Leung, F.W., Ashley, S.W., Lutrin, F.J. Gastroenterology (1992) [Pubmed]
  18. Down-regulation of the dual-specificity phosphatase MKP-1 suppresses tumorigenicity of pancreatic cancer cells. Liao, Q., Guo, J., Kleeff, J., Zimmermann, A., Büchler, M.W., Korc, M., Friess, H. Gastroenterology (2003) [Pubmed]
  19. Alpha 1 antitrypsin phenotypes and alcoholic pancreatitis. Haber, P.S., Wilson, J.S., McGarity, B.H., Hall, W., Thomas, M.C., Pirola, R.C. Gut (1991) [Pubmed]
  20. Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance. Andrianifahanana, M., Moniaux, N., Schmied, B.M., Ringel, J., Friess, H., Hollingsworth, M.A., Büchler, M.W., Aubert, J.P., Batra, S.K. Clin. Cancer Res. (2001) [Pubmed]
  21. Relationship between pancreatic exocrine function and histological changes in chronic pancreatitis. Hayakawa, T., Kondo, T., Shibata, T., Noda, A., Suzuki, T., Nakano, S. Am. J. Gastroenterol. (1992) [Pubmed]
  22. Genetic alterations in chronic pancreatitis: evidence for early occurrence of p53 but not K-ras mutations. Gansauge, S., Schmid, R.M., Muller, J., Adler, G., Mattfeldt, T., Beger, H.G. The British journal of surgery. (1998) [Pubmed]
  23. Quantitative trait locus analysis for chronic pancreatitis and diabetes mellitus in the WBN/Kob rat. Tsuji, A., Nishikawa, T., Mori, M., Suda, K., Nishimori, I., Nishimura, M. Genomics (2001) [Pubmed]
  24. Biglycan is overexpressed in pancreatic cancer and induces G1-arrest in pancreatic cancer cell lines. Weber, C.K., Sommer, G., Michl, P., Fensterer, H., Weimer, M., Gansauge, F., Leder, G., Adler, G., Gress, T.M. Gastroenterology (2001) [Pubmed]
  25. Non-ulcer dyspepsia: potential causes and pathophysiology. Talley, N.J., Phillips, S.F. Ann. Intern. Med. (1988) [Pubmed]
  26. Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia. Caldas, C., Hahn, S.A., Hruban, R.H., Redston, M.S., Yeo, C.J., Kern, S.E. Cancer Res. (1994) [Pubmed]
  27. Phosphatidylserine receptor in chronic pancreatitis: evidence for a macrophage independent role. Köninger, J., Balaz, P., Wagner, M., Shi, X., Cima, I., Zimmermann, A., di Sebastiano, P., Büchler, M.W., Friess, H. Ann. Surg. (2005) [Pubmed]
  28. Screening practices for mutations in the CFTR gene ABCC7. Girodon-Boulandet, E., Cazeneuve, C., Goossens, M. Hum. Mutat. (2000) [Pubmed]
  29. Distribution of CCK1 and CCK2 receptors in normal and diseased human pancreatic tissue. Reubi, J.C., Waser, B., Gugger, M., Friess, H., Kleeff, J., Kayed, H., Büchler, M.W., Laissue, J.A. Gastroenterology (2003) [Pubmed]
  30. Differential expression of chemokines in normal pancreas and in chronic pancreatitis. Saurer, L., Reber, P., Schaffner, T., Büchler, M.W., Buri, C., Kappeler, A., Walz, A., Friess, H., Mueller, C. Gastroenterology (2000) [Pubmed]
  31. Systemic treatment with epidermal growth factor in pigs induces ductal proliferations in the pancreas. Vinter-Jensen, L., Juhl, C.O., Teglbjaerg, P.S., Poulsen, S.S., Dajani, E.Z., Nexø, E. Gastroenterology (1997) [Pubmed]
  32. Increased expression of acidic and basic fibroblast growth factors in chronic pancreatitis. Friess, H., Yamanaka, Y., Büchler, M., Beger, H.G., Do, D.A., Kobrin, M.S., Korc, M. Am. J. Pathol. (1994) [Pubmed]
  33. In-vitro test of haptocorrin degradation for biological diagnosis of exocrine pancreatic dysfunction using duodenal juice collected during endoscopy. Guéant, J.L., Champigneulle, B., Djalali, M., Bigard, M.A., Gaucher, P., Hassouni, A., Nicolas, J.P. Lancet (1986) [Pubmed]
  34. Chronic pancreatitis is associated with increased concentrations of epidermal growth factor receptor, transforming growth factor alpha, and phospholipase C gamma. Korc, M., Friess, H., Yamanaka, Y., Kobrin, M.S., Buchler, M., Beger, H.G. Gut (1994) [Pubmed]
  35. Phospholipase A2 isoforms are altered in chronic pancreatitis. Kashiwagi, M., Friess, H., Uhl, W., Graber, H., Duarte, R., Zimmermann, A., Büchler, M.W. Ann. Surg. (1998) [Pubmed]
  36. Gastric inhibitory polypeptide (GIP), gastrin and insulin: response to test meal in coeliac disease and after duodeno-pancreatectomy. Creutzfeldt, W., Ebert, R., Arnold, R., Freichs, H., Brown, J.C. Diabetologia (1976) [Pubmed]
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