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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130.

Leukemia inhibitory factor ( LIF) is a cytokine with a broad range of activities that in many cases parallel those of interleukin-6 ( IL-6) although LIF and IL-6 appear to be structurally unrelated. A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental cDNA library. The LIF receptor is related to the gp130 'signal-transducing' component of the IL-6 receptor and to the G-CSF receptor, with the transmembrane and cytoplasmic regions of the LIF receptor and gp130 being most closely related. This relationship suggests a common signal transduction pathway for the two receptors and may help to explain similar biological effects of the two ligands. Murine cDNAs encoding soluble LIF receptors were isolated by cross-hybridization and share 70% amino acid sequence identity to the human sequence.[1]

References

  1. Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. Gearing, D.P., Thut, C.J., VandeBos, T., Gimpel, S.D., Delaney, P.B., King, J., Price, V., Cosman, D., Beckmann, M.P. EMBO J. (1991) [Pubmed]
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