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Masuyama, H. et al.

Hisashi Masuyama, Yoko Tateishi, Miwa Matsuda, Yuji Hiramatrsu,

Hyperreactio luteinalis with both markedly elevated human chorionic gonadotropin levels and an imbalance of angiogenic factors subsequently developed severe early-onset preeclampsia.

OBJECTIVE: To report a case of hyperreactio luteinalis (HL) with elevated levels of human chorionic gonadotropin (hCG) and a severe imbalance of angiogenic factors, which developed into severe, early onset preeclampsia (PE). DESIGN: Case report. SETTING: University perinatal center. PATIENT(S): A 32-year-old primigravida woman with HL, high hCG levels, and severe imbalance of angiogenic factors who subsequently developed severe PE. INTERVENTION(S): Emergent cesarean section due to nonreassuring fetal status. MAIN OUTCOME MEASURE(S): Severe, early onset PE. RESULT(S): A case of HL was referred to our hospital for remarkably elevated hCG levels and bilaterally enlarged multicystic ovaries in the first trimester; the patient subsequently developed severe, early onset PE with a severe imbalance of angiogenic factors. Emergency cesarean section was performed, and she delivered a premature female infant weighing 1818 g at 32 week's gestational age. During her next pregnancy, the circulating levels of hCG and angiogenic factors remained normal, and she did not develop either PE or HL. CONCLUSION(S): Although HL complicated with PE is very rare, our case suggests that HL associated with both an elevated hCG level and an imbalance of angiogenic factors might be a risk/predictive factor for severe, early onset PE.[1]

References

Hyperreactio luteinalis with both markedly elevated human chorionic gonadotropin levels and an imbalance of angiogenic factors subsequently developed severe early-onset preeclampsia. Masuyama, H., Tateishi, Y., Matsuda, M., Hiramatrsu, Y. Fertil. Steril. (2009) [Pubmed]

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