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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cesarean Section

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Disease relevance of Cesarean Section


Psychiatry related information on Cesarean Section


High impact information on Cesarean Section

  • We report that PS1-/- mice die shortly after natural birth or Caesarean section [11].
  • METHODS: We performed a population-based, longitudinal study of 6138 women in Nova Scotia who had previously undergone cesarean section and had delivered a singleton live infant in the period from 1986 through 1992 [12].
  • For the women assigned to active management (n = 351), the cesarean-section rate was 10.5 percent, as compared with 14.1 percent for those assigned to traditional management (n = 354, P = 0.18) [13].
  • OBJECTIVE.--We performed a meta-analysis of the six published controlled trials to estimate more precisely (1) the magnitude of protection of aspirin from PIH; (2) the effect of aspirin on severe low-birth-weight infants, cesarean section, and perinatal mortality; and (3) the risk of adverse effects [14].
  • Seven months later, acute HB occurred in a patient two months after a cesarean section, resulting in exclusion of the surgeon from major operations [15].

Chemical compound and disease context of Cesarean Section


Biological context of Cesarean Section


Anatomical context of Cesarean Section


Associations of Cesarean Section with chemical compounds

  • Importantly, the spontaneous IEC activation occurred in vaginally born mice but not in neonates delivered by Caesarean section or in TLR4-deficient mice, which together with local endotoxin measurements identified LPS as stimulatory agent [31].
  • To study the effects of ET(A) blockade at birth, 15 animals were delivered by cesarean section and ventilated with 10% oxygen (O2), 100% O2 and inhaled nitric oxide (NO) [32].
  • We have shown that a baby's stress (saliva cortisol) and crying response to inoculation at 8 weeks was related to mode of delivery, with the greatest response shown in those born by assisted delivery and the least response in those born by elective caesarean section [33].
  • 37 women in the misoprostol group and 34 in the oxytocin group had emergency caesarean sections and were excluded [34].
  • Fetal and neonatal hazards of maternal hydration with 5% dextrose before caesarean section [35].

Gene context of Cesarean Section

  • Myometrial samples collected from women in labor during lower segment cesarean section expressed 15-fold higher levels of Cox-2 messenger ribonucleic acid (mRNA) compared to myometrial specimens collected from women not in labor, as detected by Northern blot analysis [36].
  • To evaluate whether PPAR-alpha and -delta subtypes are present in intrauterine tissues, placentae were obtained from women at term after spontaneous vaginal delivery (TSL; n = 15) and elective caesarean section before labor (TNL; n = 15) [37].
  • Interferon-gamma production in response to either the mitogen phytohemagglutinin or anti-CD2/CD3/CD28 F(ab')3 was significantly reduced by neonatal mononuclear cells compared with adult cells but did not differ with mode of delivery at term (normal vaginal delivery versus elective lower-segment cesarean section) [38].
  • Lifr -/- and Lifr +/+ fetuses were obtained by Cesarean section on E18 [39].
  • The goal of this study was to detect the presence of this cytokine in the myometrium of preterm and term, nonlaboring and laboring patients, and to measure serum levels of interleukin-1 beta (IL-1 beta), IL-6 and IL-8 before cesarean section [40].

Analytical, diagnostic and therapeutic context of Cesarean Section


  1. Body mass index has a greater impact on pregnancy outcomes than gestational hyperglycaemia. Ricart, W., López, J., Mozas, J., Pericot, A., Sancho, M.A., González, N., Balsells, M., Luna, R., Cortázar, A., Navarro, P., Ramírez, O., Flández, B., Pallardo, L.F., Hernández-Mijas, A., Ampudia, J., Fernández-Real, J.M., Corcoy, R. Diabetologia (2005) [Pubmed]
  2. An effective and safe protocol involving zidovudine and caesarean section to reduce vertical transmission of HIV-1 infection. Grosch-Wörner, I., Schäfer, A., Obladen, M., Maier, R.F., Seel, K., Feiterna-Sperling, C., Weigel, R. AIDS (2000) [Pubmed]
  3. Astrocytic basic fibroblast growth factor expression in dopaminergic regions after perinatal anoxia. Flores, C., Stewart, J., Salmaso, N., Zhang, Y., Boksa, P. Biol. Psychiatry (2002) [Pubmed]
  4. Gestational diabetes: is a higher cesarean section rate inevitable? Moses, R.G., Knights, S.J., Lucas, E.M., Moses, M., Russell, K.G., Coleman, K.J., Davis, W.S. Diabetes Care (2000) [Pubmed]
  5. Randomized comparison of ceftazidime versus clindamycin-tobramycin in the treatment of obstetrical and gynecological infections. Blanco, J.D., Gibbs, R.S., Duff, P., Castaneda, Y.S., St Clair, P.J. Antimicrob. Agents Chemother. (1983) [Pubmed]
  6. Effects of brain antiestrogen implants on maternal behavior and on postpartum estrus in pregnant rats. Ahdieh, H.B., Mayer, A.D., Rosenblatt, J.S. Neuroendocrinology (1987) [Pubmed]
  7. Wakefulness during cesarean section after anesthetic induction with ketamine, thiopental, or ketamine and thiopental combined. Schultetus, R.R., Hill, C.R., Dharamraj, C.M., Banner, T.E., Berman, L.S. Anesth. Analg. (1986) [Pubmed]
  8. Hyperactivity and altered amphetamine sensitivity in premature juvenile rats. Blanchard, B.A., LeFevre, R., Mankes, R.F., Glick, S.D. Brain Res. Dev. Brain Res. (1992) [Pubmed]
  9. Expanding the clinical picture of Simpson-Golabi-Behmel syndrome. Young, E.L., Wishnow, R., Nigro, M.A. Pediatric neurology. (2006) [Pubmed]
  10. Metoclopramide induced akathisia during cesarean section. Mandal, N.G., Hutchinson, W. International journal of obstetric anesthesia. (2001) [Pubmed]
  11. Skeletal and CNS defects in Presenilin-1-deficient mice. Shen, J., Bronson, R.T., Chen, D.F., Xia, W., Selkoe, D.J., Tonegawa, S. Cell (1997) [Pubmed]
  12. Comparison of a trial of labor with an elective second cesarean section. McMahon, M.J., Luther, E.R., Bowes, W.A., Olshan, A.F. N. Engl. J. Med. (1996) [Pubmed]
  13. A controlled trial of a program for the active management of labor. López-Zeno, J.A., Peaceman, A.M., Adashek, J.A., Socol, M.L. N. Engl. J. Med. (1992) [Pubmed]
  14. A meta-analysis of low-dose aspirin for the prevention of pregnancy-induced hypertensive disease. Imperiale, T.F., Petrulis, A.S. JAMA (1991) [Pubmed]
  15. Transmission of hepatitis B with resultant restriction of surgical practice. Lettau, L.A., Smith, J.D., Williams, D., Lundquist, W.D., Cruz, F., Sikes, R.K., Hadler, S.C. JAMA (1986) [Pubmed]
  16. Effect of pregnancy and pain on cerebrospinal fluid immunoreactive enkephalins and norepinephrine in healthy humans. Eisenach, J.C., Dobson, C.E., Inturrisi, C.E., Hood, D.D., Agner, P.B. Pain (1990) [Pubmed]
  17. Prospective cost analysis of moxalactam versus clindamycin plus gentamicin for endomyometritis after cesarean section. Knodel, L.C., Goldspiel, B.R., Gibbs, R.S. Antimicrob. Agents Chemother. (1988) [Pubmed]
  18. Comparison of metaraminol and ephedrine infusions for maintaining arterial pressure during spinal anesthesia for elective cesarean section. Ngan Kee, W.D., Lau, T.K., Khaw, K.S., Lee, B.B. Anesthesiology (2001) [Pubmed]
  19. Sevoflurane induction for emergency cesarean section in a parturient in status asthmaticus. Que, J.C., Lusaya, V.O. Anesthesiology (1999) [Pubmed]
  20. Birth insult increases amphetamine-induced behavioral responses in the adult rat. El-Khodor, B.F., Boksa, P. Neuroscience (1998) [Pubmed]
  21. Pleural and pericardial pressures limit fetal right ventricular output. Grant, D.A., Walker, A.M. Circulation (1996) [Pubmed]
  22. The concentration of circulating corticotropin-releasing hormone mRNA in maternal plasma is increased in preeclampsia. Ng, E.K., Leung, T.N., Tsui, N.B., Lau, T.K., Panesar, N.S., Chiu, R.W., Lo, Y.M. Clin. Chem. (2003) [Pubmed]
  23. Possible involvement of aminopeptidase A in hypertension in spontaneously hypertensive rats (SHRs) and change of refractoriness in response to angiotensin II in pregnant SHRs. Nakashima, Y., Ohno, Y., Itakura, A., Takeuchi, M., Murata, Y., Kuno, N., Mizutani, S. J. Hypertens. (2002) [Pubmed]
  24. Pharmacokinetics and plasma binding of thiopental. II: Studies at cesarean section. Morgan, D.J., Blackman, G.L., Paull, J.D., Wolf, L.J. Anesthesiology (1981) [Pubmed]
  25. Oxyhemoglobin saturation following cesarean section in patients receiving epidural morphine, PCA, or im meperidine analgesia. Brose, W.G., Cohen, S.E. Anesthesiology (1989) [Pubmed]
  26. Amniotic fluid interleukin 6 in preterm labor. Association with infection. Romero, R., Avila, C., Santhanam, U., Sehgal, P.B. J. Clin. Invest. (1990) [Pubmed]
  27. Maternal cocaine treatment alters dynorphin and enkephalin mRNA expression in brains of fetal rhesus macaques. Chai, L., Choi, W.S., Rönnekleiv, O.K. J. Neurosci. (1997) [Pubmed]
  28. Impaired glucose transport and insulin receptor tyrosine phosphorylation in skeletal muscle from obese women with gestational diabetes. Friedman, J.E., Ishizuka, T., Shao, J., Huston, L., Highman, T., Catalano, P. Diabetes (1999) [Pubmed]
  29. Effects of dexamethasone on fetal and maternal thyroxine, triiodothyronine, reverse triiodothyronine, and thyrotropin levels. Osathanondh, R., Chopra, I.J., Tulchinsky, D. J. Clin. Endocrinol. Metab. (1978) [Pubmed]
  30. Serum thyrotropin, prolactin, and growth hormone levels during the early neonatal period in the human infant. Sack, J., Fisher, D.A., Wang, C.C. J. Pediatr. (1976) [Pubmed]
  31. Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells. Lotz, M., Gütle, D., Walther, S., Ménard, S., Bogdan, C., Hornef, M.W. J. Exp. Med. (2006) [Pubmed]
  32. Prolonged endothelin A receptor blockade attenuates chronic pulmonary hypertension in the ovine fetus. Ivy, D.D., Parker, T.A., Ziegler, J.W., Galan, H.L., Kinsella, J.P., Tuder, R.M., Abman, S.H. J. Clin. Invest. (1997) [Pubmed]
  33. Mode of delivery and subsequent stress response. Taylor, A., Fisk, N.M., Glover, V. Lancet (2000) [Pubmed]
  34. WHO multicentre randomised trial of misoprostol in the management of the third stage of labour. Gülmezoglu, A.M., Villar, J., Ngoc, N.T., Piaggio, G., Carroli, G., Adetoro, L., Abdel-Aleem, H., Cheng, L., Hofmeyr, G., Lumbiganon, P., Unger, C., Prendiville, W., Pinol, A., Elbourne, D., El-Refaey, H., Schulz, K. Lancet (2001) [Pubmed]
  35. Fetal and neonatal hazards of maternal hydration with 5% dextrose before caesarean section. Kenepp, N.B., Kumar, S., Shelley, W.C., Stanley, C.A., Gabbe, S.G., Gutsche, B.B. Lancet (1982) [Pubmed]
  36. Expression of cyclooxygenase-2 and prostanoid receptors by human myometrium. Erkinheimo, T.L., Saukkonen, K., Narko, K., Jalkanen, J., Ylikorkala, O., Ristimäki, A. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  37. Peroxisome proliferator-activated receptor isoform expression changes in human gestational tissues with labor at term. Berry, E.B., Eykholt, R., Helliwell, R.J., Gilmour, R.S., Mitchell, M.D., Marvin, K.W. Mol. Pharmacol. (2003) [Pubmed]
  38. The effect of labor on neonatal T-cell phenotype and function. Thornton, C.A., Capristo, C.C., Power, L.L., Holloway, J.A., Popplewell, E.J., Diaper, N.D., Warner, J.O. Pediatr. Res. (2003) [Pubmed]
  39. Leukemia inhibitory factor signaling is implicated in embrionic development of the HPA axis. Ware, C.B., Kariagina, A., Zonis, S., Alon, D., Chesnokova, V. FEBS Lett. (2005) [Pubmed]
  40. Immunolocalization of transforming growth factor-beta 3 in pregnant human myometrium. Kuşcu, N.K., Laçin, S., Vatansever, S., Yildirim, Y., Var, A., Uyanik, B.S., Koyuncu, F. Acta obstetricia et gynecologica Scandinavica. (2001) [Pubmed]
  41. Stress hormones and acid-base status of human fetuses at delivery. Ramin, S.M., Porter, J.C., Gilstrap, L.C., Rosenfeld, C.R. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  42. Patient variables and the subarachnoid spread of hyperbaric bupivacaine in the term parturient. Norris, M.C. Anesthesiology (1990) [Pubmed]
  43. High-volume spinal anesthesia with bupivacaine 0.125% for cesarean section. Van Zundert, A.A., De Wolf, A.M., Vaes, L., Soetens, M. Anesthesiology (1988) [Pubmed]
  44. Administration of metoclopramide for prevention of nausea and vomiting during epidural anesthesia for elective cesarean section. Chestnut, D.H., Vandewalker, G.E., Owen, C.L., Bates, J.N., Choi, W.W. Anesthesiology (1987) [Pubmed]
  45. Chloroprocaine vs. bupivacaine for lumbar epidural analgesia for elective cesarean section. James, F.M., Dewan, D.M., Floyd, H.M., Wheeler, A.S., Grant, W.M., Rhyne, L., Westmoreland, R.T. Anesthesiology (1980) [Pubmed]
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