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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity.

AFN-1252, a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibited all clinical isolates of Staphylococcus aureus (n = 502) and Staphylococcus epidermidis (n = 51) tested, including methicillin (meticillin)-resistant isolates, at concentrations of <or=0.12 microg/ml. In contrast, AFN-1252 was inactive (MIC(90), >4 microg/ml) against clinical isolates of Streptococcus pneumoniae, beta-hemolytic streptococci, Enterococcus spp., Enterobacteriaceae, nonfermentative gram-negative bacilli, and Moraxella catarrhalis. These data support the continued development of AFN-1252 for the treatment of patients with resistant staphylococcal infections.[1]

References

  1. AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. Karlowsky, J.A., Kaplan, N., Hafkin, B., Hoban, D.J., Zhanel, G.G. Antimicrob. Agents Chemother. (2009) [Pubmed]
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