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Chemical Compound Review

Meticillin     (2R,5R,6S)-6-[(2,6- dimethoxyphenyl)carbony...

Synonyms: Dimocillin, Metacillin, Meticilina, Methycillin, Meticillina, ...
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Disease relevance of methicillin


Psychiatry related information on methicillin


High impact information on methicillin


Chemical compound and disease context of methicillin

  • Gentamicin and antiseptic resistance in epidemic methicillin-resistant Staphylococcus aureus [15].
  • Because ramoplanin is structurally less complex than glycopeptide antibiotics such as vancomycin, peptidomimetic chemotherapeutics derived from this recognition sequence may find future use as antibiotics against vancomycin-resistant Enterococcus faecium, methicillin-resistant Staphylococcus aureus, and related pathogens [16].
  • An analogue of isoleucyl-adenylate (Ile-AMS) potently inhibits the isoleucyl-tRNA synthetases (IleRSs) from the three primary kingdoms, whereas the antibiotic mupirocin inhibits only the eubacterial and archaeal IleRSs, but not the eukaryotic enzymes, and therefore is clinically used against methicillin-resistant Staphylococcus aureus [17].
  • Laboratory mutants of Staphylococcus aureus strain ATCC 8325 (27S) selected for increased minimal inhibitory concentration (MIC) values to methicillin and cefotaxime showed increased rates of cell wall turnover and detergent-induced autolysis in virtual parallel with the increasing MIC for the antibiotic [18].
  • All seven patients patronized a local "shooting gallery" where paraphernalia were provided and drugs were often administered by a "street doctor." All isolates were phage type 29/77/83A/84/85 and demonstrated resistance only to methicillin, oxacillin, and penicillin [19].

Biological context of methicillin


Anatomical context of methicillin


Associations of methicillin with other chemical compounds


Gene context of methicillin


Analytical, diagnostic and therapeutic context of methicillin


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  26. Selective decontamination of the digestive tract and methicillin-resistant Staphylococcus aureus. Kaufhold, A., Behrendt, W., Kräuss, T., van Saene, H. Lancet (1992) [Pubmed]
  27. Effectiveness of cloxacillin with and without gentamicin in short-term therapy for right-sided Staphylococcus aureus endocarditis. A randomized, controlled trial. Ribera, E., Gómez-Jimenez, J., Cortes, E., del Valle, O., Planes, A., Gonzalez-Alujas, T., Almirante, B., Ocaña, I., Pahissa, A. Ann. Intern. Med. (1996) [Pubmed]
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