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MeSH Review

Staphylococcus epidermidis

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Disease relevance of Staphylococcus epidermidis


High impact information on Staphylococcus epidermidis


Chemical compound and disease context of Staphylococcus epidermidis


Biological context of Staphylococcus epidermidis


Anatomical context of Staphylococcus epidermidis

  • Ingestion of Staphylococcus epidermidis by normal neutrophils was shown to be partially inhibited by monoclonal antibodies to the alpha-chain of either CR3 or LFA-1, and monoclonal antibody to the common beta-chain inhibited ingestion by 75% [21].
  • The migration-enhancing activity of Staphylococcus epidermidis cell walls was retained by a monomer as well as a polymer of disaccharide peptides which were prepared by digestion of the peptidoglycan with enzymes [22].
  • Of importance is the observation that human monocytes infected with L. tropica for 6 hr and then challenged with a potent IL-1 inducer (Staphylococcus epidermidis) produced significantly less IL-1 than did uninfected monocytes that were similarly challenged (P less than .001) [23].
  • Glycocalyx partially purified under endotoxin-free conditions from defined liquid medium cultures of Staphylococcus lugdunensis or Staphylococcus epidermidis was a strong stimulator of PGE2 and IL-1 production [24].
  • We used transposon (Tn) mutagenesis to study the role of capsular polysaccharide/adhesin (PS/A) and slime in adherence of Staphylococcus epidermidis to catheters. pLTV1, containing Tn917-LTV1, was transformed into S. epidermidis M187 by protoplast fusion with S. aureus RN4220(pLTV1), creating M187(pLTV1) [25].

Gene context of Staphylococcus epidermidis


Analytical, diagnostic and therapeutic context of Staphylococcus epidermidis


  1. Rifampin therapy of Staphylococcus epidermidis. Use in infections from indwelling artificial devices. Archer, G.L., Tenenbaum, M.J., Haywood, H.B. JAMA (1978) [Pubmed]
  2. A prospective randomized trial evaluating prophylactic antibiotics to prevent triple-lumen catheter-related sepsis in patients treated with immunotherapy. Bock, S.N., Lee, R.E., Fisher, B., Rubin, J.T., Schwartzentruber, D.J., Wei, J.P., Callender, D.P., Yang, J.C., Lotze, M.T., Pizzo, P.A. J. Clin. Oncol. (1990) [Pubmed]
  3. Effects of infection on oxygen consumption and core temperature in experimental thermal injury. Aulick, L.H., McManus, A.T., Mason, A.D., Pruitt, B.A. Ann. Surg. (1986) [Pubmed]
  4. Structural analysis of dispersin B, a biofilm-releasing glycoside hydrolase from the periodontopathogen Actinobacillus actinomycetemcomitans. Ramasubbu, N., Thomas, L.M., Ragunath, C., Kaplan, J.B. J. Mol. Biol. (2005) [Pubmed]
  5. Intracellular pathways involved in tumor necrosis factor-alpha release by human monocytes on stimulation with lipopolysaccharide or staphylococcal peptidoglycan are partly similar. Mattsson, E., Van Dijk, H., Van Kessel, K., Verhoef, J., Fleer, A., Rollof, J. J. Infect. Dis. (1996) [Pubmed]
  6. Killing of gram-negative bacteria by polymorphonuclear leukocytes: role of an O2-independent bactericidal system. Weiss, J., Victor, M., Stendhal, O., Elsbach, P. J. Clin. Invest. (1982) [Pubmed]
  7. Ciprofloxacin-resistant Staphylococcus epidermidis and hands. Burnie, J.P., Loudon, K.W. Lancet (1997) [Pubmed]
  8. IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma. Reznikov, L.L., Kim, S.H., Westcott, J.Y., Frishman, J., Fantuzzi, G., Novick, D., Rubinstein, M., Dinarello, C.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  9. The pathogenic role of Staphylococcus epidermidis capsular polysaccharide/adhesin in a low-inoculum rabbit model of prosthetic valve endocarditis. Shiro, H., Meluleni, G., Groll, A., Muller, E., Tosteson, T.D., Goldmann, D.A., Pier, G.B. Circulation (1995) [Pubmed]
  10. Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Schindler, R., Mancilla, J., Endres, S., Ghorbani, R., Clark, S.C., Dinarello, C.A. Blood (1990) [Pubmed]
  11. Pathogenesis of infections related to intravascular catheterization. Goldmann, D.A., Pier, G.B. Clin. Microbiol. Rev. (1993) [Pubmed]
  12. Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin. Hajjar, A.M., O'Mahony, D.S., Ozinsky, A., Underhill, D.M., Aderem, A., Klebanoff, S.J., Wilson, C.B. J. Immunol. (2001) [Pubmed]
  13. Staphylococcal endocarditis. Laboratory and clinical basis for antibiotic therapy. Karchmer, A.W. Am. J. Med. (1985) [Pubmed]
  14. Evidence for autolysin-mediated primary attachment of Staphylococcus epidermidis to a polystyrene surface. Heilmann, C., Hussain, M., Peters, G., Götz, F. Mol. Microbiol. (1997) [Pubmed]
  15. Endocarditis associated with porcine valve xenografts. Downham, W.H., Rhoades, E.R. Arch. Intern. Med. (1979) [Pubmed]
  16. A novel mechanism of phase variation of virulence in Staphylococcus epidermidis: evidence for control of the polysaccharide intercellular adhesin synthesis by alternating insertion and excision of the insertion sequence element IS256. Ziebuhr, W., Krimmer, V., Rachid, S., Lössner, I., Götz, F., Hacker, J. Mol. Microbiol. (1999) [Pubmed]
  17. Penicillin and tetracycline resistance plasmids in Staphylococcus epidermidis. Totten, P.A., Vidal, L., Baldwin, J.N. Antimicrob. Agents Chemother. (1981) [Pubmed]
  18. Ciprofloxacin resistance in coagulase-positive and -negative staphylococci: role of mutations at serine 84 in the DNA gyrase A protein of Staphylococcus aureus and Staphylococcus epidermidis. Sreedharan, S., Peterson, L.R., Fisher, L.M. Antimicrob. Agents Chemother. (1991) [Pubmed]
  19. mecA is not involved in the sigmaB-dependent switch of the expression phenotype of methicillin resistance in Staphylococcus epidermidis. Knobloch, J.K., Jäger, S., Huck, J., Horstkotte, M.A., Mack, D. Antimicrob. Agents Chemother. (2005) [Pubmed]
  20. Essential functional role of the polysaccharide intercellular adhesin of Staphylococcus epidermidis in hemagglutination. Mack, D., Riedewald, J., Rohde, H., Magnus, T., Feucht, H.H., Elsner, H.A., Laufs, R., Rupp, M.E. Infect. Immun. (1999) [Pubmed]
  21. Characterization of patients with an increased susceptibility to bacterial infections and a genetic deficiency of leukocyte membrane complement receptor type 3 and the related membrane antigen LFA-1. Ross, G.D., Thompson, R.A., Walport, M.J., Springer, T.A., Watson, J.V., Ward, R.H., Lida, J., Newman, S.L., Harrison, R.A., Lachmann, P.J. Blood (1985) [Pubmed]
  22. Stimulation of migration of human monocytes by bacterial cell walls and muramyl peptides. Ogawa, T., Kotani, S., Fukuda, K., Tsukamoto, Y., Mori, M., Kusumoto, S., Shiba, T. Infect. Immun. (1982) [Pubmed]
  23. Parasite-monocyte interactions in human leishmaniasis: production of interleukin-1 in vitro. Crawford, G.D., Wyler, D.J., Dinarello, C.A. J. Infect. Dis. (1985) [Pubmed]
  24. Staphylococcal glycocalyx activates macrophage prostaglandin E2 and interleukin 1 production and modulates tumor necrosis factor alpha and nitric oxide production. Stout, R.D., Li, Y., Miller, A.R., Lambe, D.W. Infect. Immun. (1994) [Pubmed]
  25. Isolation and characterization of transposon mutants of Staphylococcus epidermidis deficient in capsular polysaccharide/adhesin and slime. Muller, E., Hübner, J., Gutierrez, N., Takeda, S., Goldmann, D.A., Pier, G.B. Infect. Immun. (1993) [Pubmed]
  26. Synthesis of interleukin-1 beta in primary biliary cirrhosis: relationship to treatment with methotrexate or colchicine and disease progression. Miller, L.C., Sharma, A., McKusick, A.F., Tassoni, J.P., Dinarello, C.A., Kaplan, M.M. Hepatology (1995) [Pubmed]
  27. Frequency of disinfectant resistance genes and genetic linkage with beta-lactamase transposon Tn552 among clinical staphylococci. Sidhu, M.S., Heir, E., Leegaard, T., Wiger, K., Holck, A. Antimicrob. Agents Chemother. (2002) [Pubmed]
  28. Transcription, translation and secretion of interleukin 1 and tumor necrosis factor: effects of tebufelone, a dual cyclooxygenase/5-lipoxygenase inhibitor. Sirko, S.P., Schindler, R., Doyle, M.J., Weisman, S.M., Dinarello, C.A. Eur. J. Immunol. (1991) [Pubmed]
  29. Cloning and characterization of a novel, plasmid-encoded trimethoprim-resistant dihydrofolate reductase from Staphylococcus haemolyticus MUR313. Dale, G.E., Langen, H., Page, M.G., Then, R.L., Stüber, D. Antimicrob. Agents Chemother. (1995) [Pubmed]
  30. CD40 ligand (CD154) takes part in regulation of the transition to mononuclear cell dominance during peritonitis. Mazar, J., Agur, T., Rogachev, B., Ziv, N.Y., Zlotnik, M., Chaimovitz, C., Douvdevani, A. Kidney Int. (2005) [Pubmed]
  31. Bacterial adherence of Staphylococcus epidermidis to intraocular lenses: a bioluminescence and scanning electron microscopy study. Kodjikian, L., Burillon, C., Roques, C., Pellon, G., Freney, J., Renaud, F.N. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  32. Related clones containing SCCmec type IV predominate among clinically significant Staphylococcus epidermidis isolates. Wisplinghoff, H., Rosato, A.E., Enright, M.C., Noto, M., Craig, W., Archer, G.L. Antimicrob. Agents Chemother. (2003) [Pubmed]
  33. Antibiotic prophylaxis of experimental endocarditis due to methicillin-resistant Staphylococcus epidermidis. Archer, G.L., Vazquez, G.J., Johnston, J.L. J. Infect. Dis. (1980) [Pubmed]
  34. Effect of the imidazole derivative lombazole on the ultrastructure of Staphylococcus epidermidis and Candida albicans. Barug, D., de Groot, K. Antimicrob. Agents Chemother. (1985) [Pubmed]
  35. Antibacterial action of structurally diverse cationic peptides on gram-positive bacteria. Friedrich, C.L., Moyles, D., Beveridge, T.J., Hancock, R.E. Antimicrob. Agents Chemother. (2000) [Pubmed]
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