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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The augmenting activity of 6-(methylsulfinyl)hexyl isothiocyanate on cellular glutathione levels is less sensitive to thiol compounds than its cytotoxic activity.

We analyzed the effects of thiol compounds on the biological activities of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC). Thiol compounds abolished the cytotoxic activity of 6-MITC, but did not abolish its activity augmenting cellular total glutathione levels and gamma-glutamylcysteine ligase gene expression. Thiol compounds might play an important role in the augmentation of several significant biological activities by overcoming the inherent limitations of 6-MITC.[1]

References

  1. The augmenting activity of 6-(methylsulfinyl)hexyl isothiocyanate on cellular glutathione levels is less sensitive to thiol compounds than its cytotoxic activity. Kidachi, Y., Noshita, T., Yamaguchi, H., Umetsu, H., Fuke, Y., Ryoyama, K. Biosci. Biotechnol. Biochem. (2009) [Pubmed]
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