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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Serum trypsin inhibitory capacity in hemodialysis patients.

It has been established that overproduction of reactive oxygen species (ROS) occurs during hemodialysis causing oxidation of proteins. Alpha-1-antitrypsin is the major circulating anti-protease which contains methionine in the active site. The aim of the present study was to measure the level of serum trypsin inhibitory capacity (sTIC) in hemodialysis patients. This case-control study was performed in 52 hemodialysis patients and 49 healthy controls. sTIC was measured by enzymatic assay. The sTIC was significantly (P< 0.001) lower in hemodialysis patients (1.87 +/- 0.67 micromol/min/mL) than healthy controls (2.83 +/- 0.44 micromol/min/L). Reduction of sTIC may be due to the oxidation of methionine residue in the reactive site of alpha-1 antitrypsin.[1]

References

  1. Serum trypsin inhibitory capacity in hemodialysis patients. Hashemi, M., Mehrabifar, H., Homayooni, F., Naderi, M., Montazerifar, F., Ghavami, S. Saudi. J. Kidney. Dis. Transpl (2009) [Pubmed]
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