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Chemical Compound Review

Pedameth     2-amino-4-methylsulfanyl- butanoic acid

Synonyms: Lobamine, Acimetion, Cynaron, Meonine, Mertionin, ...
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Disease relevance of methionine


High impact information on methionine


Chemical compound and disease context of methionine


Biological context of methionine


Anatomical context of methionine

  • These results provide a biochemical explanation of equimolar incorporation of HMB and DL-methionine (DL-Met) into chick hepatocyte protein in that the two HMB enzymes can simultaneously convert both HMB isomers to L-Met while only one enzyme, D-2-amino acid oxidase, converts D-Met to L-Met [21].
  • A direct relationship between dietary copper, and the concentration of copper in livers or plasmas was demonstrated in chicks fed either the basal diet or the basal diet supplemented with 1.5% DL-methionine [1].
  • Performance, breast meat yield and abdominal fat deposition of male broiler chickens fed diets supplemented with DL-methionine or DL-methionine hydroxy analogue free acid [22].
  • In week 21, all goats were injected intraperitoneally with 1 g/d DL-methionine for 5 d to establish the effects of methionine under the conditions of udder stress induced by hand milking on the second day [23].
  • These results indicate that DL-methionine and ammonium sulfate accelerated urinary Ca excretion and reduced Ca retention in the extracellular fluid [24].

Associations of methionine with other chemical compounds

  • L-Cystine was substituted for DL-methionine to supplement the casein component [25].
  • Therefore, Met2 is not essential for biologic activity and substitution of Lys is synthetically advantageous [26].
  • Chicks fed the basal diet had increased growth when given supplements of either folic acid, choline Cl, or DL-methionine, but not vitamin B12 [27].
  • L-Lysine monohydrochloride was supplemented with or without DL-methionine twice daily through the reticular groove, except in Trial 4, in which N supplements were infused through duodenal cannulas [28].
  • Male and female weanling Sprague-Dawley rats were fed either an AIN-76A diet or a modification of the AIN-76A diet containing no added DL-methionine but with higher levels of vitamins, fluoride and magnesium than in the AIN-76A diet [29].
  • There were no significant differences in homocysteine remethylation or methionine transsulfuration and transmethylation between the groups at clinical phase 1 [30].
  • Elucidating the relationship between lysine and methionine synthesis may lead to new ways of producing transgenic crop plants containing increased methionine and lysine levels, thus improving their nutritional quality [31].
  • The methionine used by the GIT was metabolized into homocysteine (31%), CO(2) (40%), or tissue protein (29%) [32].
  • In certain species, the fidelity of translation of methionine codons requires a discrimination mechanism that is independent of the information contained in the anticodon [33].

Gene context of methionine

  • Most chromaffin cells which stained for tyrosine hydroxylase contained VIP-like immunoreactivity, whereas methionine- (Met-) and leucine- (Leu-) enkephalin-like immunoreactivity was detected in about 40% of the cells revealed by the anti-tyrosine hydroxylase serum [34].
  • D. alata feeding did not significantly change hepatic superoxide dismutase, glutathione peroxidase, and glutathione reductase, which were adaptively enhanced by Met feeding [14].
  • In addition, Met- and Leu-enkephalins (10(-5) M) did not alter the production of corticosterone induced by ACTH [34].
  • The hepatic catalase in the Met + D2 and Met + D3 groups was significantly elevated compared to that in the Met group [14].
  • Protein quality measured as protein efficiency ratio (PER) gave low values for the non-supplemented lupin proteins (1.34 semi-sweet variety; 1.53 water-extracted seeds; 1.19 oil-cake; 3.09 casein), but the PER's were improved by the addition of 0.2% DL-methionine to the diets (3.05, 2.69, 2,81, respectively) [35].

Analytical, diagnostic and therapeutic context of methionine

  • In accordance, a significant decrease of FIGLU excretion was observed in the patients after oral administration of DL-methionine for 4 days [36].
  • At birth, the pups from dams fed the low-protein diets supplemented with 0.2% dl-methionine or greater were significantly smaller than those of the dams fed the diet containing 18% protein [37].
  • In Trial 1, postruminal administration of 6 g of DL-methionine/d increased ADG, feed intake, gain/feed, and N retention compared with a control group receiving N-free supplement [38].
  • In the first experiment, Met (dl-methionine) and Lys (l-lysine-HCl) were added to diets used in continuous culture bioreactors to estimate optimal concentrations for use in subsequent in vivo experiments [39].


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  2. Methionine-cystine interrelations in chicks fed diets containing suboptimal levels of methionine. Featherston, W.R., Rogler, J.C. J. Nutr. (1978) [Pubmed]
  3. Altered regulation of the glnRA operon in a Bacillus subtilis mutant that produces methionine sulfoximine-tolerant glutamine synthetase. Schreier, H.J., Rostkowski, C.A., Kellner, E.M. J. Bacteriol. (1993) [Pubmed]
  4. The translation initiation site of recombinant Trypanosoma brucei ornithine decarboxylase varies with different promoters. Kuntz, D.A., Phillips, M.A., Moore, T.D., Craig, S.P., Bass, K.E., Wang, C.C. Mol. Biochem. Parasitol. (1992) [Pubmed]
  5. Biological efficacy and absorption of DL-methionine hydroxy analogue free acid compared to DL-methionine in chickens as affected by heat stress. Rostagno, H.S., Barbosa, W.A. Br. Poult. Sci. (1995) [Pubmed]
  6. Early effects of copper accumulation on methionine metabolism. Delgado, M., Pérez-Miguelsanz, J., Garrido, F., Rodríguez-Tarduchy, G., Pérez-Sala, D., Pajares, M.A. Cell. Mol. Life Sci. (2008) [Pubmed]
  7. Methionine metabolism and liver disease. Mato, J.M., Martínez-Chantar, M.L., Lu, S.C. Annu. Rev. Nutr. (2008) [Pubmed]
  8. Loss of the oncogene from human H-ras-1-transfected NIH/3T3 cells grown in the presence of excess methionine. Hillova, J., Hill, M., Belehradek, J., Mariage-Samson, R., Brada, Z. J. Natl. Cancer Inst. (1986) [Pubmed]
  9. YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: A study by in vitro full-length viral DNA transfection. Ono-Nita, S.K., Kato, N., Shiratori, Y., Masaki, T., Lan, K.H., Carrilho, F.J., Omata, M. Hepatology (1999) [Pubmed]
  10. Steroid-binding and dimerization domains of human sex hormone-binding globulin partially overlap: steroids and Ca2+ stabilize dimer formation. Bocchinfuso, W.P., Hammond, G.L. Biochemistry (1994) [Pubmed]
  11. The inhibition by methionine and choline of liver carcinoma formation in male C3H mice dosed with diethylnitrosamine and fed phenobarbital. Fullerton, F.R., Hoover, K., Mikol, Y.B., Creasia, D.A., Poirier, L.A. Carcinogenesis (1990) [Pubmed]
  12. Excess dietary methionine markedly increases the vitamin B-6 requirement of young chicks. Scherer, C.S., Baker, D.H. J. Nutr. (2000) [Pubmed]
  13. Dietary soybean isolate and methionine supplementation affect mammary tumor progression in rats. Hawrylewicz, E.J., Huang, H.H., Blair, W.H. J. Nutr. (1991) [Pubmed]
  14. Chinese yam (Dioscorea alata cv. Tainung No. 2) feeding exhibited antioxidative effects in hyperhomocysteinemia rats. Chang, S.J., Lee, Y.C., Liu, S.Y., Chang, T.W. J. Agric. Food Chem. (2004) [Pubmed]
  15. Protein, methionine, lysine and a fermentation residue as variables in diets of young turkeys. Potter, L.M., Shelton, J.R. Poult. Sci. (1976) [Pubmed]
  16. Methionine, cystine, sodium sulfate, and Fermacto-500 supplementation of practical-type diets for young turkeys. Potter, L.M., Shelton, J.R. Poult. Sci. (1984) [Pubmed]
  17. Adverse effects of excess DL-methionine in calves with different body weights. Abe, M., Iriki, T., Koresawa, Y., Inoue, K., Funaba, M. J. Anim. Sci. (1999) [Pubmed]
  18. Whole rat embryos require methionine for neural tube closure when cultured on cow serum. Coelho, C.N., Weber, J.A., Klein, N.W., Daniels, W.G., Hoagland, T.A. J. Nutr. (1989) [Pubmed]
  19. Effect of excess dietary methionine on rat pregnancy: influence on ovarian delta5-3beta-hydroxysteroid dehydrogenase activity. Chandrashekar, V., Leathem, J.H. Fertil. Steril. (1977) [Pubmed]
  20. Estimation of bioavailability of DL-methionine hydroxy analogue relative to DL-methionine in layers with exponential and slope-ratio models. Liu, Z., Bateman, A., Bryant, M., Abebe, A., Roland, D. Poult. Sci. (2004) [Pubmed]
  21. Conversion of 2-hydroxy-4-(methylthio)butanoic acid to L-methionine in the chick: a stereospecific pathway. Dibner, J.J., Knight, C.D. J. Nutr. (1984) [Pubmed]
  22. Performance, breast meat yield and abdominal fat deposition of male broiler chickens fed diets supplemented with DL-methionine or DL-methionine hydroxy analogue free acid. Esteve-Garcia, E., Llauradó, L.L. Br. Poult. Sci. (1997) [Pubmed]
  23. Effects of dietary supplements of zinc-methionine on milk production, udder health and zinc metabolism in dairy goats. Salama, A.A., Caja, G., Albanell, E., Such, X., Casals, R., Plaixats, J. J. Dairy Res. (2003) [Pubmed]
  24. Hypercalciuric response to dietary supplementation with DL-methionine and ammonium sulfate. Lent, A.J., Wideman, R.F. Poult. Sci. (1994) [Pubmed]
  25. Components of the AIN-93 diets as improvements in the AIN-76A diet. Reeves, P.G. J. Nutr. (1997) [Pubmed]
  26. Synthetic peptide derived from alpha-fetoprotein inhibits growth of human breast cancer: investigation of the pharmacophore and synthesis optimization. DeFreest, L.A., Mesfin, F.B., Joseph, L., McLeod, D.J., Stallmer, A., Reddy, S., Balulad, S.S., Jacobson, H.I., Andersen, T.T., Bennett, J.A. J. Pept. Res. (2004) [Pubmed]
  27. Folate deficiency in chicks fed diets containing practical ingredients. Pesti, G.M., Rowland, G.N., Ryu, K.S. Poult. Sci. (1991) [Pubmed]
  28. Lysine deficiency in postweaned calves fed corn and corn gluten meal diets. Abe, M., Iriki, T., Funaba, M. J. Anim. Sci. (1997) [Pubmed]
  29. Nutritional and pathological changes in male and female rats fed modifications of the AIN-76A diet. Mitchell, G.V., Dua, P.N., Jenkins, M., Grundel, E. Food Chem. Toxicol. (1989) [Pubmed]
  30. Sulfur amino acid metabolism in children with severe childhood undernutrition: methionine kinetics. Jahoor, F., Badaloo, A., Reid, M., Forrester, T. Am. J. Clin. Nutr. (2006) [Pubmed]
  31. Lysine enhances methionine content by modulating the expression of S-adenosylmethionine synthase. Hacham, Y., Song, L., Schuster, G., Amir, R. Plant J. (2007) [Pubmed]
  32. Methionine transmethylation and transsulfuration in the piglet gastrointestinal tract. Riedijk, M.A., Stoll, B., Chacko, S., Schierbeek, H., Sunehag, A.L., van Goudoever, J.B., Burrin, D.G. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  33. An operational RNA code for faithful assignment of AUG triplets to methionine. Jones, T.E., Brown, C.L., Geslain, R., Alexander, R.W., Ribas de Pouplana, L. Mol. Cell (2008) [Pubmed]
  34. Co-localization of vasoactive intestinal peptide (VIP) and enkephalins in chromaffin cells of the adrenal gland of amphibia. Stimulation of corticosteroid production by VIP. Leboulenger, F., Leroux, P., Delarue, C., Tonon, M.C., Charnay, Y., Dubois, P.M., Coy, D.H., Vaudry, H. Life Sci. (1983) [Pubmed]
  35. Composition and protein quality of Lupinus mutabilis. Schoeneberger, H., Gross, R., Cremer, H.D., Elmadfa, I. J. Nutr. (1982) [Pubmed]
  36. Inter-relationships between single carbon units' metabolism and resting energy expenditure in weight-losing patients with small cell lung cancer. Effects of methionine supply and chemotherapy. Sengeløv, H., Hansen, O.P., Simonsen, L., Bülow, J., Nielsen, O.J., Ovesen, L. Eur. J. Cancer (1994) [Pubmed]
  37. An imbalance in the methionine content of the maternal diet reduces postnatal growth in the rat. Rees, W.D., Hay, S.M., Cruickshank, M. Metab. Clin. Exp. (2006) [Pubmed]
  38. Methionine imbalance and toxicity in calves. Abe, M., Okada, H., Matsumura, D., Sato, H., Funaba, M., Iriki, T. J. Anim. Sci. (2000) [Pubmed]
  39. Effects of methionine and lysine on fermentation in vitro and in vivo, nutrient flow to the intestine, and milk production. Chung, Y.H., Bateman, H.G., Williams, C.C., Stanley, C.C., Gantt, D.T., Braud, T.W., Southern, L.L., Ward, J.D., Hoyt, P.G., Sod, G.A. J. Dairy Sci. (2006) [Pubmed]
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