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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide.

A polyamide nucleic acid (PNA) was designed by detaching the deoxyribose phosphate backbone of DNA in a computer model and replacing it with an achiral polyamide backbone. On the basis of this model, oligomers consisting of thymine-linked aminoethylglycyl units were prepared. These oligomers recognize their complementary target in double-stranded DNA by strand displacement. The displacement is made possible by the extraordinarily high stability of the PNA-DNA hybrids. The results show that the backbone of DNA can be replaced by a polyamide, with the resulting oligomer retaining base-specific hybridization.[1]

References

  1. Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Nielsen, P.E., Egholm, M., Berg, R.H., Buchardt, O. Science (1991) [Pubmed]
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