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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Genotyping of the Spanish cystic fibrosis population at the delta F508 mutation site and RFLP linked loci.

Spanish families (n = 75) with at least one affected cystic fibrosis ( CF) child were typed for restriction fragment length polymorphisms (RFLPs) by the probes XV2c, KM19, and pMP6d-9. These families were also studied at the 508 mutation site by the polymerase chain reaction method. We have studied the linkage disequilibrium between these markers and the CF mutations, the probable number of independent secondary CFX (non-delta F508) mutations, and the genetic differences between Spain and Western Europe.[1]

References

  1. Genotyping of the Spanish cystic fibrosis population at the delta F508 mutation site and RFLP linked loci. Jaume-Roig, B., Simon-Bouy, B., Taillandier, A., Serre, J.L., Antich, J., Bellon, J., Boué, J., Boué, A. Hum. Genet. (1990) [Pubmed]
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