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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A reappraisal of the significance of largest basal diameter of posterior uveal melanoma.

OBJECTIVES: To evaluate the significance of the largest tumour diameter (LTD) of posterior uveal melanomas (ie, involving choroid), correlating this feature with histological and cytogenetic predictors and mortality. METHODS: Patients with posterior uveal melanoma were included. LTD was measured by echography and correlated with histological and cytogenetic findings and metastatic death. RESULTS: The cohort comprised 1776 patients with a median age of 60 years, a median tumour diameter of 14.0 mm, and a median tumour height of 7.5 mm. The LTD was greater in older patients (t-test, P<0.001). The presence of epithelioid cells, closed loops, high mitotic rate, chromosome 3 deletion, and chromosome 8 gains all correlated significantly with LTD (t-test, P<0.001). The 1521 British patients had a median follow-up of 4.9 years, with a disease-specific mortality of 28.9%. Metastatic death correlated with LTD (Cox multivariate analysis, P<0.001). Tumours with the same LTD showed significant variation in survival, according to the presence of epithelioid cells (Log rank, P<0.001), closed loops (Log rank, P=0.002), high mitotic rate (Log rank, P=0.003), and chromosome 3 loss (Log rank, P=0.008). CONCLUSIONS: The value of LTD as a predictor of survival after treatment of posterior uveal melanoma is enhanced by taking histological and cytogenetic factors into account.[1]


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