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MeSH Review

Epithelioid Cells

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Disease relevance of Epithelioid Cells


High impact information on Epithelioid Cells

  • ICAM-1 purified from the HeLa epithelioid cell line and reconstituted into planar membranes also supported efficient adhesion of T lymphoblasts that was blocked by LFA-1 mAb bound to the T lymphoblasts or ICAM-1 mAb bound to the planar membranes [6].
  • Moreover, we show here for the first time that the expression of exogenous Fra-1 in epithelioid cells results in morphological changes that resemble fibroblastoid conversion [7].
  • No expression from the IFN-alpha-CAT hybrid gene was detected in 293 cells, indicating that human epithelioid cells lack a factor required for expression of the IFN-alpha promoter [8].
  • These included a major population of acid phosphatase and nonspecific esterase-positive macrophage-like cells and a minor population of factor VII antigen negative epithelioid cells [9].
  • Biopsy revealed biphasic neoplasm displaying nests of poorly differentiated neuroblastic cells positive for synaptophysin and pigmented cuboidal epithelioid cell positive for keratins, epithelial membrane antigen and MHB-45 [10].

Chemical compound and disease context of Epithelioid Cells


Biological context of Epithelioid Cells


Anatomical context of Epithelioid Cells


Associations of Epithelioid Cells with chemical compounds


Gene context of Epithelioid Cells

  • One-third of large congenital nevi expressed CD40 in small clusters of heavily pigmented, epithelioid cells, corresponding to so-called proliferative nodules [31].
  • Tumours containing epithelioid cells showed a significantly higher expression of HLA-B than tumours of the spindle cell type [32].
  • In addition, cyclin D1 positivity was associated with the presence of extraocular extension of the tumour (p=0.01), with the mixed or epithelioid cell type (p=0. 02), and with the tumour cell MIB-1 positivity (p=0.0001) [33].
  • In this small series, no statistically significant associations between the presence of the BRAF mutation and clinicopathological characteristics were detected, although tumors with this mutation tended to have a larger diameter and greater depth of invasion and to contain epithelioid cells [34].
  • Immunohistochemically, the epithelioid cells showed strong positive reaction for Factor VIII in all three patients, for CD31 in two, and for CD34 in one [35].

Analytical, diagnostic and therapeutic context of Epithelioid Cells


  1. Enhanced production of TGF-beta by blood monocytes from patients with active tuberculosis and presence of TGF-beta in tuberculous granulomatous lung lesions. Toossi, Z., Gogate, P., Shiratsuchi, H., Young, T., Ellner, J.J. J. Immunol. (1995) [Pubmed]
  2. Epstein-barr virus infection of monocytoid B-cell proliferates: an early feature of primary viral infection? Anagnostopoulos, I., Hummel, M., Falini, B., Joehrens, K., Stein, H. Am. J. Surg. Pathol. (2005) [Pubmed]
  3. Immunohistochemical localization of renin in the human kidney. Faraggiana, T., Gresik, E., Tanaka, T., Inagami, T., Lupo, A. J. Histochem. Cytochem. (1982) [Pubmed]
  4. Small gastrointestinal stromal tumor concomitant with early gastric cancer: a case report. Lin, Y.L., Tzeng, J.E., Wei, C.K., Lin, C.W. World J. Gastroenterol. (2006) [Pubmed]
  5. Immunohistochemical and molecular assessment of human herpesvirus type 8 in gastrointestinal tumours. Su, C.C., Li, C.F., Liao, Y.L., Lin, C.N., Lu, J.J. J. Clin. Pathol. (2005) [Pubmed]
  6. Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon gamma and is mediated by intercellular adhesion molecule 1 (ICAM-1). Dustin, M.L., Singer, K.H., Tuck, D.T., Springer, T.A. J. Exp. Med. (1988) [Pubmed]
  7. Fra-1 induces morphological transformation and increases in vitro invasiveness and motility of epithelioid adenocarcinoma cells. Kustikova, O., Kramerov, D., Grigorian, M., Berezin, V., Bock, E., Lukanidin, E., Tulchinsky, E. Mol. Cell. Biol. (1998) [Pubmed]
  8. Transient expression of the beta interferon promoter in human cells. Xanthoudakis, S., Alper, D., Hiscott, J. Mol. Cell. Biol. (1987) [Pubmed]
  9. Hematopoietic regulatory factors produced in long-term murine bone marrow cultures and the effect of in vitro irradiation. Gualtieri, R.J., Shadduck, R.K., Baker, D.G., Quesenberry, P.J. Blood (1984) [Pubmed]
  10. December 2004: one-year-old girl with aggressive skull tumor. Al-Otaibi, M., Lach, B., Al Shail, E. Brain Pathol. (2005) [Pubmed]
  11. Experimental granulomas induced by mycobacterial immune complexes in rats. Ridley, M.J., Marianayagam, Y., Spector, W.G. J. Pathol. (1982) [Pubmed]
  12. Ultrastructural observations on epithelioid cell granulomas induced by zirconium in the guinea-pig. Turk, J.L., Badenoch-Jones, P., Parker, D. J. Pathol. (1978) [Pubmed]
  13. Contrasting effects of hydroxyurea on cell growth and reduction in Epstein-Barr virus genomes in EBV-infected epithelioid cell lines vs Burkitt's lymphoma cell lines. Jiang, R., Kanamori, M., Satoh, Y., Fukuda, M., Ikuta, K., Murakami, M., Sairenji, T. J. Med. Virol. (2003) [Pubmed]
  14. Macrophage differentiation and granulomatous inflammation in osteopetrotic mice (op/op) defective in the production of CSF-1. Naito, M., Umeda, S., Takahashi, K., Shultz, L.D. Mol. Reprod. Dev. (1997) [Pubmed]
  15. Alpha-naphthyl acetate esterase-1 (ANAE-1) secreted by epithelioid cells from induced rabbit lung granuloma showed MIF activity. Miyazaki, E., Tsuda, T., Abe, Y., Sugisaki, K., Sigenaga, T. Exp. Lung Res. (1992) [Pubmed]
  16. Involvement of the IP-10 chemokine in sarcoid granulomatous reactions. Agostini, C., Cassatella, M., Zambello, R., Trentin, L., Gasperini, S., Perin, A., Piazza, F., Siviero, M., Facco, M., Dziejman, M., Chilosi, M., Qin, S., Luster, A.D., Semenzato, G. J. Immunol. (1998) [Pubmed]
  17. Markers of cell proliferation and expression of melanosomal antigen in lymphangioleiomyomatosis. Matsumoto, Y., Horiba, K., Usuki, J., Chu, S.C., Ferrans, V.J., Moss, J. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  18. Benign vascular neoplasms of the spleen with myoid and angioendotheliomatous features. Kraus, M.D., Dehner, L.P. Histopathology (1999) [Pubmed]
  19. Tachyphylaxis of juxtaglomerular epithelioid cells to angiotensin II. Differences between the electrical membrane response and renin secretion. Bührle, C.P., Hackenthal, E., Nobiling, R., Skøtt, O., Baumbach, L., Taugner, R. Pflugers Arch. (1987) [Pubmed]
  20. Influence of pulsatile perfusion upon renin release from the isolated perfused rat kidney. Nobiling, R., Münter, K., Bührle, C.P., Hackenthal, E. Pflugers Arch. (1990) [Pubmed]
  21. The neutrophil chemoattractant produced by the rat kidney epithelioid cell line NRK-52E is a protein related to the KC/gro protein. Watanabe, K., Konishi, K., Fujioka, M., Kinoshita, S., Nakagawa, H. J. Biol. Chem. (1989) [Pubmed]
  22. Surface markers on lymphocytes and cells of the mononuclear phagocyte series in skin sections in leprosy. Ridley, M.J., Ridley, D.S., Turk, J.L. J. Pathol. (1978) [Pubmed]
  23. Modulation of the morphology and glycosaminoglycan biosynthesis of human monocytes, induced by culture substrates. Kolset, S.O., Seljelid, R., Lindahl, U. Biochem. J. (1984) [Pubmed]
  24. Sensitization with Cr, Ni and Zr salts and allergic type granuloma formation in the guinea pig. Turk, J.L., Parker, D. J. Invest. Dermatol. (1977) [Pubmed]
  25. Epithelioid cells from foreign-body granuloma selectively express the calcium-binding protein MRP-14, a novel down-regulatory molecule of macrophage activation. Aguiar-Passeti, T., Postol, E., Sorg, C., Mariano, M. J. Leukoc. Biol. (1997) [Pubmed]
  26. The dynamics of chromatin carcinogen interactions in the human cell. Kootstra, A. Nucleic Acids Res. (1986) [Pubmed]
  27. Isolated epithelioid cells from disaggregated BCG granulomas - some functional studies. Williams, G.T. J. Pathol. (1982) [Pubmed]
  28. Defective phagocytic ability of epithelioid cells reversed by levamisole. Mariano, M., Malucelli, B.E. J. Pathol. (1980) [Pubmed]
  29. Characteristics of 5-HT-containing chemoreceptor cells of the chicken aortic body. Ito, S., Ohta, T., Nakazato, Y. J. Physiol. (Lond.) (1999) [Pubmed]
  30. The cyclic AMP-dependent initiation of DNA synthesis by T51B rat liver epithelioid cells. Boynton, A.L., Whitfield, J.F. J. Cell. Physiol. (1979) [Pubmed]
  31. CD40 is a prognostic marker in primary cutaneous malignant melanoma. van den Oord, J.J., Maes, A., Stas, M., Nuyts, J., Battocchio, S., Kasran, A., Garmyn, M., De Wever, I., De Wolf-Peeters, C. Am. J. Pathol. (1996) [Pubmed]
  32. Inverse correlation between expression of HLA-B and c-myc in uveal melanoma. Blom, D.J., Mooy, C.M., Luyten, G.P., Kerkvliet, S., Ouwerkerk, I., Zwinderman, A.H., Schrier, P.I., Jager, M.J. J. Pathol. (1997) [Pubmed]
  33. The prognostic value of cyclin D1, p53, and MDM2 protein expression in uveal melanoma. Coupland, S.E., Anastassiou, G., Stang, A., Schilling, H., Anagnostopoulos, I., Bornfeld, N., Stein, H. J. Pathol. (2000) [Pubmed]
  34. BRAF mutations in conjunctival melanoma. Gear, H., Williams, H., Kemp, E.G., Roberts, F. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  35. Epithelioid hemangioma of small tubular bones: a report of three cases, two of them associated with pregnancy. Lamovec, J., Bracko, M. Mod. Pathol. (1996) [Pubmed]
  36. Leiomyosarcoma of somatic soft tissues in childhood: an immunohistochemical analysis of six cases with ultrastructural correlation. Swanson, P.E., Wick, M.R., Dehner, L.P. Hum. Pathol. (1991) [Pubmed]
  37. Nitrergic innervation and nitrergic cells in arteriovenous anastomoses. Funk, R.H., Mayer, B., Wörl, J. Cell Tissue Res. (1994) [Pubmed]
  38. Glucose metabolism and pathological findings in uveal melanoma: preliminary results. Modorati, G., Lucignani, G., Landoni, C., Freschi, M., Trabucchi, G., Fazio, F., Brancato, R. Nuclear medicine communications. (1996) [Pubmed]
  39. Fine-needle aspiration of hepatocellular carcinoma: False-negative result due to epithelioid cells. Mourra, N., Flejou, J.F. Diagn. Cytopathol. (2001) [Pubmed]
  40. Electron microscopy of granulomatous lesions of the liver in primary biliary cirrhosis. Tobe, K., Itoshima, T., Tsuchiya, T., Fujiwara, R., Yamada, G., Nagashima, H., Kobayashi, T. Acta Pathol. Jpn. (1985) [Pubmed]
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