- Chromosome 17 polysomy without human epidermal growth factor receptor 2 amplification does not predict response to lapatinib plus paclitaxel compared with paclitaxel in metastatic breast cancer. Downey, L., Livingston, R.B., Koehler, M., Arbushites, M., Williams, L., Santiago, A., Guzman, R., Villalobos, I., Di Leo, A., Press, M.F. Clin. Cancer Res. (2010)