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Irreversible, direct bonding of nanoporous polymer membranes to PDMS or glass microdevices.

A method for integrating porous polymer membranes such as polycarbonate, polyethersulfone and polyethylene terephthalate to microfluidic devices is described. The use of 3-aminopropyltriethoxysilane as a chemical crosslinking agent was extended to integrate membranes with PDMS and glass microfluidic channels. A strong, irreversible bond between the membranes and microfluidic structure was achieved. The bonding strength in the APTES treated devices was significantly greater than in devices fabricated using either a PDMS "glue" or two-part epoxy bonding method. Evaluation of a filtering microdevice and the pore structure via SEM indicates the APTES conjugation does not significantly alter the membrane transport function and pore morphology.[1]


  1. Irreversible, direct bonding of nanoporous polymer membranes to PDMS or glass microdevices. Aran, K., Sasso, L.A., Kamdar, N., Zahn, J.D. Lab. Chip (2010) [Pubmed]
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