Sodium requirement for the positive inotropic action of isoproterenol on guinea pig atria.
Isoproterenol doses not elicit its characteristic positive inotropic action in contracting guinea pig atria suspended in sodium-free media. However, the ability of isoproterenol to decrease the time to peak tension development during an individual contraction cycle is still present in sodium-free solutions. Removal of sodium diminished but did not eliminate the tissues' ability to elevate adenosine 3',5'-monophosphate in response to isoproterenol. The striking absence of an inotropic action by isoproterenol on atria in sodium-free media suggests that sodium (and possibly a sodium-calcium exchange across the sarcolemma) plays an important role in the inotropic action of catecholamines.[1]References
- Sodium requirement for the positive inotropic action of isoproterenol on guinea pig atria. Linden, J., Brooker, G. Science (1978) [Pubmed]
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