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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A practical and azide-free synthetic approach to oseltamivir from diethyl D-tartrate.

A short and practical synthesis of oseltamivir was accomplished in 11 steps from inexpensive and abundant diethyl D-tartrate starting material. This azide-free route featured an asymmetric aza-Henry reaction and a domino nitro-Michael/Horner-Wadsworth-Emmons (HWE) reaction as the key steps to construct the relevant cyclohexene ring of the product, which provided an economical and practical alternative for the synthesis of oseltamivir.[1]

References

  1. A practical and azide-free synthetic approach to oseltamivir from diethyl D-tartrate. Weng, J., Li, Y.B., Wang, R.B., Li, F.Q., Liu, C., Chan, A.S., Lu, G. J. Org. Chem. (2010) [Pubmed]
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