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Chemical Compound Review

D-Tartrate     (2S,3S)-2,3- dihydroxybutanedioic acid

Synonyms: tartaric acid, T206_ALDRICH, T400_ALDRICH, AG-L-22101, CHEMBL1200861, ...
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Disease relevance of tartaric acid


High impact information on tartaric acid

  • 3. Ninety-three per cent of the total enzyme activity detected in the supernatant exposed to bone-osteoclast preparations was resistant to inhibition by D-tartaric acid and was bound to an antibody known to be highly specific for the osteoclast-derived isoenzyme, showing that it originated from osteoclasts [6].
  • The results demonstrate a clear predominance of both SGI1-borne resistance genes and class 1 integrons in Salmonella serovar Typhimurium DT104 and of class 2 integrons in Salmonella serovar Paratyphi B (d-tartrate positive) [7].
  • Sequence data revealed a nucleotide exchange from G to A within the ATG start codon of gene STM 3356 in the d-tartrate-nonfermenting strains [8].
  • Effects of the new class I antiarrhythmic agent Ro 22-9194, (2R)-2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide D-tartrate, on ischemia- and reperfusion-induced arrhythmias in dogs: involvement of thromboxane A2 synthase inhibitory activity [3].
  • The d-tartrate fermenting phenotype of S [5].

Biological context of tartaric acid


Anatomical context of tartaric acid


Gene context of tartaric acid

  • Twenty-two XbaI-pulsotypes were observed among the 65 dT- strains while 17 XbaI-pulsotypes were observed among the 22 isolates of Salm [12].

Analytical, diagnostic and therapeutic context of tartaric acid


  1. Multiple-drug resistance in D-tartrate-positive Salmonella enterica serovar paratyphi B isolates from poultry is mediated by class 2 integrons inserted into the bacterial chromosome. Miko, A., Pries, K., Schroeter, A., Helmuth, R. Antimicrob. Agents Chemother. (2003) [Pubmed]
  2. Genetic population structure, clonal phylogeny, and pathogenicity of Salmonella paratyphi B. Selander, R.K., Beltran, P., Smith, N.H., Barker, R.M., Crichton, P.B., Old, D.C., Musser, J.M., Whittam, T.S. Infect. Immun. (1990) [Pubmed]
  3. Effects of the new class I antiarrhythmic agent Ro 22-9194, (2R)-2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide D-tartrate, on ischemia- and reperfusion-induced arrhythmias in dogs: involvement of thromboxane A2 synthase inhibitory activity. Murakami, M., Kinukawa, M., Kanazawa, T., Maruyama, K., Miyagi, M., Miyata, H., Ujiie, A. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  4. Rotational therapy with a colchicine analog in chronic granulocytic leukemia. Stolinsky, D.C., Weiner, J.M., Bateman, J.R. Oncology (1980) [Pubmed]
  5. Isolation of Salmonella enterica subspecies enterica serovar Paratyphi B dT+, or Salmonella Java, from Indonesia and alteration of the d-tartrate fermentation phenotype by disrupting the ORF STM 3356. Han, K.H., Choi, S.Y., Lee, J.H., Lee, H., Shin, E.H., Agtini, M.D., von Seidlein, L., Ochiai, R.L., Clemens, J.D., Wain, J., Hahn, J.S., Lee, B.K., Song, M., Chun, J., Kim, D.W. J. Med. Microbiol. (2006) [Pubmed]
  6. Intracellular regulation of enzyme secretion from rat osteoclasts and evidence for a functional role in bone resorption. Moonga, B.S., Moss, D.W., Patchell, A., Zaidi, M. J. Physiol. (Lond.) (1990) [Pubmed]
  7. Molecular mechanisms of resistance in multidrug-resistant serovars of Salmonella enterica isolated from foods in Germany. Miko, A., Pries, K., Schroeter, A., Helmuth, R. J. Antimicrob. Chemother. (2005) [Pubmed]
  8. Discrimination of d-tartrate-fermenting and -nonfermenting Salmonella enterica subsp. enterica isolates by genotypic and phenotypic methods. Malorny, B., Bunge, C., Helmuth, R. J. Clin. Microbiol. (2003) [Pubmed]
  9. Utilization of d-tartaric acid by Salmonella paratyphi B and Salmonella java: comparison of anaerobic plate test, lead acetate test and turbidity test. Barker, R.M. The Journal of hygiene. (1985) [Pubmed]
  10. Improvement of Intestinal Absorption of P-glycoprotein Substrate by D-tartaric Acid. Iida, A., Tomita, M., Idota, Y., Takizawa, Y., Hayashi, M. Drug Metab. Pharmacokinet. (2006) [Pubmed]
  11. D-tartrate alters uptake of [3H]dopamine into brain synaptic vesicles. Reith, M.E., Kramer, H.K., Sershen, H., Lajtha, A. J. Neurosci. Methods (1990) [Pubmed]
  12. DNA fingerprinting of human isolates of Salmonella enterica serotype Paratyphi B in Malaysia. Goh, Y.L., Yasin, R., Puthucheary, S.D., Koh, Y.T., Lim, V.K., Taib, Z., Thong, K.L. J. Appl. Microbiol. (2003) [Pubmed]
  13. An immunoassay of human band 5 ("tartrate-resistant") acid phosphatase that involves the use of anti-porcine uteroferrin antibodies. Whitaker, K.B., Cox, T.M., Moss, D.W. Clin. Chem. (1989) [Pubmed]
  14. Phenotypic and genotypic characterization of Salmonella enterica serotype paratyphi B isolates from environmental and human sources in Galicia, Spain. Martinez-Urtaza, J., Echeita, A., Liebana, E. J. Food Prot. (2006) [Pubmed]
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