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Cutolo, M. et al.

Maurizio Cutolo, Barbara Villaggio, Carmen Pizzorni, Sabrina Paolino, Stefano Moretti, Fabio Gallo, Stefano Bonassi, Alberto Sulli, Bruno Seriolo, Paola Montagna, Stefano Soldano,

Inflammatory gene profile in early rheumatoid arthritis and modulation by leflunomide and prednisone treatment.

The effects of low dose prednisone (PD) alone or in combination with leflunomide (LEF) were tested on inflammatory gene expression in early rheumatoid arthritis (RA). Ten RA patients were assigned as group A (untreated)and group B (pretreated with PD 5 mg/day for 3 months -T0). Therefore, both groups were treated with LFN (20mg/day). Expression ratio of 34 inflammatory genes was detected by microarray analysis in early RA patients and CNT (5), before (T0), and after 3 months (T1) of combined therapy (PN+LFN). At T0, 17 genes linked with arthritis were found altered in early RA, (A and B groups), compared to CNT. At T1 in the group A, 41% of genes were found unchanged, 12% upregulated, and 47% downregulated, whereas in the group B, 65% of genes were found unchanged, 6% upregulated, and 29% downregulated. The results suggest that the combination of PN and LEF seems to play a synergistic effect by modulating some inflammatory genes in early RA.[1]

References

Inflammatory gene profile in early rheumatoid arthritis and modulation by leflunomide and prednisone treatment. Cutolo, M., Villaggio, B., Pizzorni, C., Paolino, S., Moretti, S., Gallo, F., Bonassi, S., Sulli, A., Seriolo, B., Montagna, P., Soldano, S. Ann. N. Y. Acad. Sci. (2010) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg