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Brody, A.L. et al.

Arthur L. Brody, Edythe D. London, Richard E. Olmstead, Zoe Allen-Martinez, Stephanie Shulenberger, Matthew R. Costello, Anna L. Abrams, David Scheibal, Judah Farahi, Steven Shoptaw, Mark A. Mandelkern,

Smoking-induced change in intrasynaptic dopamine concentration: effect of treatment for Tobacco Dependence.

The aim of this study was to determine whether standard treatments for Tobacco Dependence affect smoking-induced changes in intrasynaptic dopamine (DA) concentration. Forty-three otherwise healthy adult cigarette smokers (10 to 40 cigarettes per day) were treated with either practical group counseling (PGC) psychotherapy (n=14), bupropion HCl (n=14), or matching pill placebo (n=15) (random assignment) for 8 weeks. Before and after treatment, each subject underwent a bolus-plus-continuous-infusion (11)C-raclopride positron emission tomography (PET) scanning session, during which he or she smoked a regular cigarette. The PET scanning outcome measure of interest was percent change in smoking-induced (11)C-raclopride binding potential (BP(ND)) in the ventral caudate/nucleus accumbens (VCD/NAc), as an indirect measure of DA release. Although the entire study sample had a smaller mean smoking-induced reduction in VCD/NAc BP(ND) after treatment (compared to before treatment), this change was highly correlated with smaller total cigarette puff volumes (and not other treatment variables). These data indicate that smoking-induced DA release is dose-dependent, and is not significantly affected by reductions in daily smoking levels or treatment type.[1]

References

Smoking-induced change in intrasynaptic dopamine concentration: effect of treatment for Tobacco Dependence. Brody, A.L., London, E.D., Olmstead, R.E., Allen-Martinez, Z., Shulenberger, S., Costello, M.R., Abrams, A.L., Scheibal, D., Farahi, J., Shoptaw, S., Mandelkern, M.A. Psychiatry. Res (2010) [Pubmed]

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