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MeSH Review

Tobacco Use Disorder

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Psychiatry related information on Tobacco Use Disorder


High impact information on Tobacco Use Disorder


Chemical compound and disease context of Tobacco Use Disorder


Biological context of Tobacco Use Disorder


Anatomical context of Tobacco Use Disorder


Gene context of Tobacco Use Disorder

  • The clinical implications of CYP2A6 polymorphisms have been linked to a decreased risk of tobacco dependence, a decrease in number of cigarettes smoked and reduced risk of tobacco-related cancers [19].
  • Allelic variants within the COMT gene are therefore potential candidates for examining interindividual differences in vulnerability to nicotine dependence (ND) [20].
  • The aim of the present study was to determine which characteristics of smoking, particularly the Fagerström Test for Nicotine Dependence (FTND) score, were associated with the risk of developing COPD [21].
  • These data provide support to the notion that the blockade of CB1 receptors can oppose tobacco dependence, withdrawal and even relapse, though the time window of efficacy and/or the schedule of administration remain to be established [22].
  • It is concluded that nicotinic receptors containing the beta2 subunit play a major role in the discriminative stimulus and taste aversion effects of nicotine that may reflect psychological aspects of tobacco dependence [23].

Analytical, diagnostic and therapeutic context of Tobacco Use Disorder


  1. Cerebrospinal fluid and plasma testosterone levels in post-traumatic stress disorder and tobacco dependence. Mulchahey, J.J., Ekhator, N.N., Zhang, H., Kasckow, J.W., Baker, D.G., Geracioti, T.D. Psychoneuroendocrinology (2001) [Pubmed]
  2. Tobacco control competencies for US medical students. Geller, A.C., Zapka, J., Brooks, K.R., Dube, C., Powers, C.A., Rigotti, N., O'Donnell, J., Ockene, J. American journal of public health. (2005) [Pubmed]
  3. Cigarette smoking is associated with unhealthy patterns of nutrient intake: a meta-analysis. Dallongeville, J., Marécaux, N., Fruchart, J.C., Amouyel, P. J. Nutr. (1998) [Pubmed]
  4. Residential (inpatient) treatment compared with outpatient treatment for nicotine dependence. Hays, J.T., Wolter, T.D., Eberman, K.M., Croghan, I.T., Offord, K.P., Hurt, R.D. Mayo Clin. Proc. (2001) [Pubmed]
  5. Clinical effectiveness of sustained-release bupropion and behavior therapy for tobacco dependence in a clinical setting. Earles, J., Folen, R.A., Ma, M., Kellar, M., Geralde, R., Dydek, C. Military medicine. (2002) [Pubmed]
  6. The effectiveness of the nicotine patch for smoking cessation. A meta-analysis. Fiore, M.C., Smith, S.S., Jorenby, D.E., Baker, T.B. JAMA (1994) [Pubmed]
  7. Attention-deficit/hyperactivity disorder in a population isolate: linkage to loci at 4q13.2, 5q33.3, 11q22, and 17p11. Arcos-Burgos, M., Castellanos, F.X., Pineda, D., Lopera, F., Palacio, J.D., Palacio, L.G., Rapoport, J.L., Berg, K., Bailey-Wilson, J.E., Muenke, M. Am. J. Hum. Genet. (2004) [Pubmed]
  8. Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence. Ma, J.Z., Beuten, J., Payne, T.J., Dupont, R.T., Elston, R.C., Li, M.D. Hum. Mol. Genet. (2005) [Pubmed]
  9. Blood cotinine levels as indicators of smoking treatment outcome. Hall, S.M., Herning, R.I., Jones, R.T., Benowitz, N.L., Jacob, P. Clin. Pharmacol. Ther. (1984) [Pubmed]
  10. Role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and nicotine replacement therapy for tobacco dependence: results of two randomized clinical trials. Lerman, C., Jepson, C., Wileyto, E.P., Epstein, L.H., Rukstalis, M., Patterson, F., Kaufmann, V., Restine, S., Hawk, L., Niaura, R., Berrettini, W. Neuropsychopharmacology (2006) [Pubmed]
  11. Tobacco dependence and the nicotine patch. Clinical guidelines for effective use. Fiore, M.C., Jorenby, D.E., Baker, T.B., Kenford, S.L. JAMA (1992) [Pubmed]
  12. Nornicotine pretreatment decreases intravenous nicotine self-administration in rats. Green, T.A., Phillips, S.B., Crooks, P.A., Dwoskin, L.P., Bardo, M.T. Psychopharmacology (Berl.) (2000) [Pubmed]
  13. Caffeine potentiates the discriminative-stimulus effects of nicotine in rats. Gasior, M., Jaszyna, M., Munzar, P., Witkin, J.M., Goldberg, S.R. Psychopharmacology (Berl.) (2002) [Pubmed]
  14. Differences in platelet serotonin transporter sites between African-American tobacco smokers and non-smokers. Patkar, A.A., Gopalakrishnan, R., Berrettini, W.H., Weinstein, S.P., Vergare, M.J., Leone, F.T. Psychopharmacology (Berl.) (2003) [Pubmed]
  15. Tobacco smoking induces expression of very-high-affinity nicotine binding sites on blood polymorphonuclear cells. Lebargy, F., Benhammou, K., Morin, D., Zini, R., Urien, S., Brée, F., Bignon, J., Branellec, A., Lagrue, G. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  16. Neuroplasticity within the mesoaccumbens dopamine system and its role in tobacco dependence. Balfour, D.J. Current drug targets. CNS and neurological disorders. (2002) [Pubmed]
  17. Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers. Beuten, J., Ma, J.Z., Payne, T.J., Dupont, R.T., Quezada, P., Huang, W., Crews, K.M., Li, M.D. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2005) [Pubmed]
  18. Pharmacological treatment of tobacco dependence. Jarvik, M.E., Henningfield, J.E. Pharmacol. Biochem. Behav. (1988) [Pubmed]
  19. Decreasing smoking behaviour and risk through CYP2A6 inhibition. Sellers, E.M., Tyndale, R.F., Fernandes, L.C. Drug Discov. Today (2003) [Pubmed]
  20. Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations. Beuten, J., Payne, T.J., Ma, J.Z., Li, M.D. Neuropsychopharmacology (2006) [Pubmed]
  21. Can cumulative tobacco consumption, FTND score, and carbon monoxide concentration in expired air be predictors of chronic obstructive pulmonary disease? Jiménez-Ruiz, C., Miravitlles, M., Sobradillo, V., Gabriel, R., Viejo, J.L., Masa, J.F., Fernández-Fau, L., Villasante, C. Nicotine Tob. Res. (2004) [Pubmed]
  22. Cannabinoid CB1 receptors are involved in motivational effects of nicotine in rats. Forget, B., Hamon, M., Thiébot, M.H. Psychopharmacology (Berl.) (2005) [Pubmed]
  23. The role of nicotinic receptor beta-2 subunits in nicotine discrimination and conditioned taste aversion. Shoaib, M., Gommans, J., Morley, A., Stolerman, I.P., Grailhe, R., Changeux, J.P. Neuropharmacology (2002) [Pubmed]
  24. Effect of a novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide, on nicotine self-administration and hyperactivity in rats. Neugebauer, N.M., Zhang, Z., Crooks, P.A., Dwoskin, L.P., Bardo, M.T. Psychopharmacology (Berl.) (2006) [Pubmed]
  25. Adoption of the AHCPR Clinical Practice Guideline for Smoking Cessation: a survey of California's HMOs. Halpin Schauffler, H., Mordavsky, J.K., McMenamin, S. American journal of preventive medicine. (2001) [Pubmed]
  26. Nicotine-dependence symptoms are associated with smoking frequency in adolescents. O'Loughlin, J., DiFranza, J., Tyndale, R.F., Meshefedjian, G., McMillan-Davey, E., Clarke, P.B., Hanley, J., Paradis, G. American journal of preventive medicine. (2003) [Pubmed]
  27. Efficacy and safety of bupropion SR for smoking cessation: data from clinical trials and five years of postmarketing experience. Ferry, L., Johnston, J.A. International journal of clinical practice. (2003) [Pubmed]
  28. Motivational factors related to quitting smoking among prisoners during a smoking ban. Cropsey, K.L., Kristeller, J.L. Addictive behaviors. (2003) [Pubmed]
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