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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Regulation of acetylcholine release from neuroblastoma x glioma hybrid cells.

Neuroblastoma x glioma NG108-15 hybrid cells exposed to N6, O2'-dibutyryladenosine 3':5'-cyclic monophosphate for several days release [3H]acetylcholine in response to serotonin, prostaglandin F2alpha, KCl, or veratridine. NG108-15 cells grown in the absence of dibutyrul cyclic AMP do not respond to an excitatory stimulus by releasing [3H]acetylcholine but can be shifted to a responsive state by treatment with dibutyryl cyclic AMP. Thus, the reactions that are required for acetylcholine release can be regulated in NG108-15 cells, thereby regulating the ability of cells to form synapses and the efficiency of synaptic communication.[1]


  1. Regulation of acetylcholine release from neuroblastoma x glioma hybrid cells. McGee, R., Simpson, P., Christian, C., Mata, M., Nelson, P., Nirenberg, M. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
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