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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The anticonflict effect of MK-801, an NMDA antagonist: investigation by punishment procedure in mice.

The NMDA antagonist MK-801 at 0.3 mg/kg, i.p. increased the punished response under a MULT VI 1.5/FR 5-punishment schedule of food reinforcement in mice. Furthermore, although neither MK-801 (0.1 mg/kg, i.p.) nor diazepam (0.25 mg/kg, s.c.) was without effect when separately administered, a significant increase in the punished response appeared after the combined administration of these two drugs. The present results suggest that MK-801 not only shows an anticonflict effect, but also enhances the anticonflict effect of benzodiazepine anxiolytics in mice.[1]

References

  1. The anticonflict effect of MK-801, an NMDA antagonist: investigation by punishment procedure in mice. Kuribara, H., Fujiwara, S., Yasuda, H., Tadokoro, S. Jpn. J. Pharmacol. (1990) [Pubmed]
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