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Gene Review

Ulbp1  -  UL16 binding protein 1

Mus musculus

Synonyms: A430108B07Rik, MULT1
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Disease relevance of Ulbp1


Psychiatry related information on Ulbp1

  • Adult BALB/c mice were injected IP with trimethyltin . HCl (TMT), and the effects of TMT were studied on gross behavior, lethality, spontaneous motor activity (SMA), and responding under a multiple fixed-ratio 30, fixed-interval 600 sec (mult FR30 FI600) schedule of reinforcement [2].

High impact information on Ulbp1

  • A distinct N-terminal module within the fcr-1 ectodomain in conjunction with the fcr-1 transmembrane domain was required to dispose MULT-1 to degradation in lysosomes [3].
  • Our findings underline the significance of escaping MULT-1/NKG2D signaling for viral survival and maintenance [1].
  • The MCMV m145-encoded glycoprotein turned out to be necessary and sufficient to regulate MULT-1 by preventing plasma membrane residence of MULT-1 [1].
  • The importance of MULT-1 in NK cell regulation in vivo was confirmed by the attenuating effect of the m145 deletion that was lifted after NK cell depletion [1].
  • We set out to define the viral gene product regulating murine UL16-binding protein-like transcript (MULT)-1, a newly described NKG2D ligand [1].

Biological context of Ulbp1


Associations of Ulbp1 with chemical compounds

  • Here we compared the molecular recognition between NKG2D and three of the known ligands, UL16 binding protein (ULBP), MHC class I-like molecule, and retinoic acid early inducible gene as observed in the ligand-complexed crystal structures [4].
  • The lowest dose of caffeine, 1 mg/kg, had no effect on responding under either component of the mult schedule [5].
  • PIA decreased responding under both components of the mult schedule in a dose-dependent, and similar, manner [5].
  • No potency differences were observed between the isomers of pentobarbital and secobarbital on the responding of mice under the mult FR30 FI600 schedule over a dose range of 1-30 mg/kg [6].
  • The NMDA antagonist MK-801 at 0.3 mg/kg, i.p. increased the punished response under a MULT VI 1.5/FR 5-punishment schedule of food reinforcement in mice [7].

Other interactions of Ulbp1

  • TLR signaling, through the MyD88 adaptor, up-regulates transcription of the retinoic acid early inducible-1 (RAE-1) family of NKG2D ligands, but not H-60 or murine UL16-binding protein-like transcript-1 [8].


  1. NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145. Krmpotic, A., Hasan, M., Loewendorf, A., Saulig, T., Halenius, A., Lenac, T., Polic, B., Bubic, I., Kriegeskorte, A., Pernjak-Pugel, E., Messerle, M., Hengel, H., Busch, D.H., Koszinowski, U.H., Jonjic, S. J. Exp. Med. (2005) [Pubmed]
  2. Behavioral toxicology of acute trimethyltin exposure in the mouse. Wenger, G.R., McMillan, D.E., Chang, L.W. Neurobehavioral toxicology and teratology. (1982) [Pubmed]
  3. The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60. Lenac, T., Budt, M., Arapovic, J., Hasan, M., Zimmermann, A., Simic, H., Krmpotic, A., Messerle, M., Ruzsics, Z., Koszinowski, U.H., Hengel, H., Jonjic, S. J. Exp. Med. (2006) [Pubmed]
  4. Making sense of the diverse ligand recognition by NKG2D. Radaev, S., Kattah, M., Zou, Z., Colonna, M., Sun, P.D. J. Immunol. (2002) [Pubmed]
  5. Behavioral effects of caffeine, (-)N-((R)-1-methyl-2-phenylethyl)-adenosine (PIA), and their combination in the mouse. Glowa, J.R., Sobel, E., Malaspina, S., Dews, P.B. Psychopharmacology (Berl.) (1985) [Pubmed]
  6. Behavioral effects of the isomers of pentobarbital and secobarbital in mice and rats. Wenger, G.R. Pharmacol. Biochem. Behav. (1986) [Pubmed]
  7. The anticonflict effect of MK-801, an NMDA antagonist: investigation by punishment procedure in mice. Kuribara, H., Fujiwara, S., Yasuda, H., Tadokoro, S. Jpn. J. Pharmacol. (1990) [Pubmed]
  8. Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. Hamerman, J.A., Ogasawara, K., Lanier, L.L. J. Immunol. (2004) [Pubmed]
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