Adrenocortical tumors: an integrated clinical, pathologic, and molecular approach at the University of Michigan.
CONTEXT: The University of Michigan Health System has a rich tradition in the study and treatment of endocrine neoplasia. Recently, an integrated clinical and research program focused on primary cancer of the adrenal gland has been developed. OBJECTIVE: To discuss the foundation of the University of Michigan Adrenal Cancer Program that consists of 3 components: (1) advancement of excellent clinical care, (2) dissemination of resources and knowledge, and (3) scientific discovery. DATA SOURCES: Recent programmatic activity includes genome-wide transcriptomic evaluation of human adrenocortical tumors for diagnostic and prognostic evaluation; interrogation of the Wnt signaling pathway in adrenocortical carcinoma, using mouse models and transcriptome profiling; and clinical trials with targeted therapy focused on inhibition of insulin-like growth factor signaling pathway. CONCLUSIONS: This review article presents an overview of this program and its recent activity.[1]References
- Adrenocortical tumors: an integrated clinical, pathologic, and molecular approach at the University of Michigan. Giordano, T.J. Arch. Pathol. Lab. Med. (2010) [Pubmed]
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