Disease relevance of Adrenal Gland Neoplasms

• We therefore examined the efficacy and toxicity of oral gossypol as a treatment for adrenal cancer in humans [1].
• Intensive multimodality therapy including paclitaxel and reduced-intensity allogeneic hematopoietic stem cell transplantation in the treatment of adrenal cancer with multiple metastases [2].
• We present a rare case of adrenal cancer with hypertension in a patient with low plasma renin activity and a low plasma aldosterone concentration [3].
• A 34-year-old man had a huge hormone-producing adrenal cancer with multiple lung metastases, direct liver invasion and a tumor thrombus in the inferior vena cava [4].

High impact information on Adrenal Gland Neoplasms

• To test this hypothesis and to study appropriate inhibitors, we used a human adrenal cancer cell line (SW-13/K-fgf) engineered to secrete Kaposi's sarcoma-derived fibroblast growth factor (K-FGF), which we previously showed to induce growth of highly vascularized subcutaneous tumors in animals by autocrine and paracrine stimuli [5].
• The adenylate cyclase of this corticosteroid-producing, transplanted, adrenal cancer of the rat was stimulated not only by adrenocorticotropic hormone and fluoride, but also by the beta-adrenergic agonist, isoproterenol [6].
• This system appears to be useful in elucidating the biochemical mechanism of mitotane action on adrenal cancer [7].
• In summary, this is the first demonstration that seladin-1/DHCR24 expression is reduced in adrenal cancer, suggesting that it might be viewed as a new potential marker of adrenal malignancies [8].
• Transcriptional inactivation of the menin gene is, hence, unlikely to cause loss of its tumor suppressor function in adrenal cancer [9].

Chemical compound and disease context of Adrenal Gland Neoplasms

• Twenty-one patients with metastatic adrenal cancer received oral gossypol at doses of 30-70 mg/day [1].
• The effect of suramin on testosterone production was evaluated in cancer patients, adult male rats, rat Leydig cells, and NCI-H295 human adrenal cancer cells [10].
• We conclude that Mitometh is not likely to be effective in the therapy of adrenal cancer [11].
• 0. Children with adrenal cancer exhibited normal or high values of cortisol, whereas cortisone levels were decreased and the cortisone/cortisol ratio was decreased to nearly zero [12].
• In a case of adrenal cancer, urinary 17OHCS again did not correlate with plasma cortisol or urinary free cortisol [13].

Biological context of Adrenal Gland Neoplasms

• The purpose of this investigation was to determine whether bcl-2 or bax gene expression differs between benign and malignant adrenal tumors, and whether hTERT gene expression correlates with the prognosis of patients with adrenal cancer [14].

Gene context of Adrenal Gland Neoplasms

• In addition, there is evidence that histone deacetylase inhibitors can further enhance the rate of adenoviral infectivity in human adrenal cancer cells [15].
• This technique is useful in removint an extensive extension of a renal or adrenal cancer into the inferior vena cava [16].

References