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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Gene Expression Profiling

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Disease relevance of Gene Expression Profiling


High impact information on Gene Expression Profiling


Chemical compound and disease context of Gene Expression Profiling


Biological context of Gene Expression Profiling


Anatomical context of Gene Expression Profiling


Associations of Gene Expression Profiling with chemical compounds


Gene context of Gene Expression Profiling

  • We searched for immediate-early cytokine responsive genes by the mRNA differential display technique using interleukin-3 (IL-3)-dependent OTT-1 cells, and have isolated a novel cDNA which encodes 210 amino acids and shows 87% amino acid identity to human SNAP-23 (synaptosomal-associated protein of 23 kD) [26].
  • Three cDNA clones, SRG1, SRG2, and SRG3, corresponding to genes with transcripts that accumulate during these late phases, were isolated by the mRNA differential display method [27].
  • Before the onset of the disease, at a nonproteinuric stage, the transcript expression analysis revealed a strong production of some macrophage-associated cytokines, particularly TNF-alpha (350-fold higher than control levels), which was corroborated by monocyte infiltration [28].
  • Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display [29].
  • Using mRNA differential display and 5'RACE we isolated human HDAC3, a novel gene that is upregulated in PHA-activated T cell clones [30].

Analytical, diagnostic and therapeutic context of Gene Expression Profiling


  1. Overexpression of dihydrodiol dehydrogenase as a prognostic marker of non-small cell lung cancer. Hsu, N.Y., Ho, H.C., Chow, K.C., Lin, T.Y., Shih, C.S., Wang, L.S., Tsai, C.M. Cancer Res. (2001) [Pubmed]
  2. Identification of HRPAP20: a novel phosphoprotein that enhances growth and survival in hormone-responsive tumor cells. Karp, C.M., Pan, H., Zhang, M., Buckley, D.J., Schuler, L.A., Buckley, A.R. Cancer Res. (2004) [Pubmed]
  3. Enhanced CD9 expression in the mouse and human brains infected with transmissible spongiform encephalopathies. Doh-ura, K., Mekada, E., Ogomori, K., Iwaki, T. J. Neuropathol. Exp. Neurol. (2000) [Pubmed]
  4. A novel gene suppressed in the ventricle of carnitine-deficient juvenile visceral steatosis mice. Masuda, M., Kobayashi, K., Horiuchi, M., Terazono, H., Yoshimura, N., Saheki, T. FEBS Lett. (1997) [Pubmed]
  5. TM7XN1, a novel human EGF-TM7-like cDNA, detected with mRNA differential display using human melanoma cell lines with different metastatic potential. Zendman, A.J., Cornelissen, I.M., Weidle, U.H., Ruiter, D.J., van Muijen, G.N. FEBS Lett. (1999) [Pubmed]
  6. MxA overexpression reveals a common genetic link in four Fanconi anemia complementation groups. Li, Y., Youssoufian, H. J. Clin. Invest. (1997) [Pubmed]
  7. Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue. Nishio, Y., Warren, C.E., Buczek-Thomas, J.A., Rulfs, J., Koya, D., Aiello, L.P., Feener, E.P., Miller, T.B., Dennis, J.W., King, G.L. J. Clin. Invest. (1995) [Pubmed]
  8. Transcriptional regulation of the human trefoil factor, TFF1, by gastrin. Khan, Z.E., Wang, T.C., Cui, G., Chi, A.L., Dimaline, R. Gastroenterology (2003) [Pubmed]
  9. Inosine-containing primers for mRNA differential display. Rohrwild, M., Alpan, R.S., Liang, P., Pardee, A.B. Trends Genet. (1995) [Pubmed]
  10. Juvenile hormone acid methyltransferase: a key regulatory enzyme for insect metamorphosis. Shinoda, T., Itoyama, K. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  11. Down-regulation of the Diphthamide biosynthesis protein 2-like gene during retinoid-induced differentiation and apoptosis: implications against its tumor-suppressor activity. Liu, G., Wu, M., Levi, G., Ferrari, N. Int. J. Cancer (2000) [Pubmed]
  12. Identification of transforming growth factor-beta1-binding protein overexpression in carmustine-resistant glioma cells by MRNA differential display. Norman, S.A., Rhodes, S.N., Treasurywala, S., Hoelzinger, D.B., Rankin Shapiro, J., Scheck, A.C. Cancer (2000) [Pubmed]
  13. Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells. Ito, A., Asamoto, M., Hokaiwado, N., Takahashi, S., Shirai, T. Cancer Lett. (2005) [Pubmed]
  14. Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation. Zhang, R., Averboukh, L., Zhu, W., Zhang, H., Jo, H., Dempsey, P.J., Coffey, R.J., Pardee, A.B., Liang, P. Mol. Cell. Biol. (1998) [Pubmed]
  15. Glucose induced genes in bovine aortic smooth muscle cells identified by mRNA differential display. Nishio, Y., Aiello, L.P., King, G.L. FASEB J. (1994) [Pubmed]
  16. Oncogenic raf-1 induces the expression of non-histone chromosomal architectural protein HMGI-C via a p44/p42 mitogen-activated protein kinase-dependent pathway in salivary epithelial cells. Li, D., Lin, H.H., McMahon, M., Ma, H., Ann, D.K. J. Biol. Chem. (1997) [Pubmed]
  17. Altered gene expression in kidneys of mice with 2,8-dihydroxyadenine nephrolithiasis. Wang, L., Raikwar, N., Deng, L., Yang, M., Liang, L., Shao, C., Evan, A.P., Stambrook, P.J., Sahota, A., Tischfield, J.A. Kidney Int. (2000) [Pubmed]
  18. Cloning of two plant cDNAs encoding a beta-type proteasome subunit and a transformer-2-like SR-related protein: early induction of the corresponding genes in tobacco cells treated with cryptogein. Petitot, A.S., Blein, J.P., Pugin, A., Suty, L. Plant Mol. Biol. (1997) [Pubmed]
  19. Testatin: a cystatin-related gene expressed during early testis development. Töhönen, V., Osterlund, C., Nordqvist, K. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  20. Alterations in skeletal muscle gene expression of ob/ob mice by mRNA differential display. Vicent, D., Piper, M., Gammeltoft, S., Maratos-Flier, E., Kahn, C.R. Diabetes (1998) [Pubmed]
  21. Identification of the osteopontin gene as a direct target of TP53. Morimoto, I., Sasaki, Y., Ishida, S., Imai, K., Tokino, T. Genes Chromosomes Cancer (2002) [Pubmed]
  22. The 70-kDa heat shock cognate protein (Hsc73) gene is enhanced by ovarian hormones in the ventromedial hypothalamus. Krebs, C.J., Jarvis, E.D., Pfaff, D.W. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  23. Metallothionein is overexpressed by hamster fibroblasts selected for growth in 15 pm folinic acid and provides a growth advantage in low folate. Zhu, W.Y., Melera, P.W. Cancer Res. (1999) [Pubmed]
  24. Thiazolidinediones downregulate stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes. Kurebayashi, S., Hirose, T., Miyashita, Y., Kasayama, S., Kishimoto, T. Diabetes (1997) [Pubmed]
  25. Identification of genes regulated by muscarinic acetylcholine receptors: application of an improved and statistically comprehensive mRNA differential display technique. von der Kammer, H., Albrecht, C., Mayhaus, M., Hoffmann, B., Stanke, G., Nitsch, R.M. Nucleic Acids Res. (1999) [Pubmed]
  26. Induction of synaptosomal-associated protein-23 kD (SNAP-23) by various cytokines. Morikawa, Y., Nishida, H., Misawa, K., Nosaka, T., Miyajima, A., Senba, E., Kitamura, T. Blood (1998) [Pubmed]
  27. Novel molecular markers for late phases of the growth cycle of Arabidopsis thaliana cell-suspension cultures are expressed during organ senescence. Callard, D., Axelos, M., Mazzolini, L. Plant Physiol. (1996) [Pubmed]
  28. Renal macrophage activation and Th2 polarization precedes the development of nephrotic syndrome in Buffalo/Mna rats. Le Berre, L., Hervé, C., Buzelin, F., Usal, C., Soulillou, J.P., Dantal, J. Kidney Int. (2005) [Pubmed]
  29. Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. Manda, R., Kohno, T., Matsuno, Y., Takenoshita, S., Kuwano, H., Yokota, J. Genomics (1999) [Pubmed]
  30. Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells. Dangond, F., Hafler, D.A., Tong, J.K., Randall, J., Kojima, R., Utku, N., Gullans, S.R. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  31. Messenger ribonucleic acids encoding a serotonin receptor and a novel gene are induced in Sertoli cells by a secreted factor(s) from male rat meiotic germ cells. Syed, V., Gomez, E., Hecht, N.B. Endocrinology (1999) [Pubmed]
  32. Expression of cell cycle/growth regulator genes in human hepatocellular carcinoma and adjacent normal liver tissues. Liu, L.X., Jiang, H.C., Liu, Z.H., Zhu, A.L., Zhang, W.H., Wu, L.F., Zhou, J., Wang, X.Q., Wu, M. Oncol. Rep. (2003) [Pubmed]
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