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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma.

To study the potential involvement of IL-6 in the development of plasmacytomas, a number of plasmacytoma lines were analyzed for alterations in the IL-6 locus. A DNA rearrangement due to the insertion of an intracisternal A particle retrotransposon 18 bp 5' of the transcriptional start site was detected in the cell line MPC11. The IL-6 gene is constitutively expressed in MPC11, suggesting the involvement of IL-6 in the development of certain myeloma/plasmacytomas according to the "autocrine growth hypothesis".[1]

References

  1. DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma. Blankenstein, T., Qin, Z.H., Li, W.Q., Diamantstein, T. J. Exp. Med. (1990) [Pubmed]
 
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