The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Iap1  -  intracisternal A particle 1

Mus musculus

Synonyms: Type I AP (p120), p73
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Iap1


High impact information on Iap1

  • Using the mouse genome sequence and an efficient ex vivo retrotransposition assay, we identified functional, master IAP copies that encode all the enzymatic and structural proteins necessary for their autonomous transposition in heterologous cells [5].
  • By introducing mutations, we found that the three genes gag, prt and pol are all required for retrotransposition and identified the IAP gene products by electron microscopy in the form of intracellular A-type particles in the transfected cells [5].
  • Role of the p53-homologue p73 in E2F1-induced apoptosis [6].
  • The p73 protein shares substantial sequence homology and functional similarity with p53 (refs 5-7 ) [6].
  • The Aiy and Avy alleles are caused by insertion of an intracisternal A particle element 1 kb or 100 kb, respectively, upstream of agouti coding sequences [7].

Chemical compound and disease context of Iap1


Biological context of Iap1


Anatomical context of Iap1


Associations of Iap1 with chemical compounds

  • Here we show that the amount of p73 protein in the cell is increased by cisplatin [15].
  • p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage [19].
  • Analysis of RNA from 16.5 mM glucose-cultured islets revealed induction of 7.2 and 5.4 kbp transcripts known to code for p73 and the p114-120 polypeptides, respectively [17].
  • Inhibition of NQO1 activity by dicoumarol induces p53 and p73 proteasomal degradation [20].
  • These data suggest that killing of p53-negative tumor cells by chemotherapy would be enhanced by integrin ligation to activate the alternative c-Abl/p73 pathway [21].

Regulatory relationships of Iap1


Other interactions of Iap1


Analytical, diagnostic and therapeutic context of Iap1


  1. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation. Lissy, N.A., Davis, P.K., Irwin, M., Kaelin, W.G., Dowdy, S.F. Nature (2000) [Pubmed]
  2. Activation of putative transposition intermediate formation in tumor cells. Grigoryan, M.S., Kramerov, D.A., Tulchinsky, E.M., Revasova, E.S., Lukanidin, E.M. EMBO J. (1985) [Pubmed]
  3. Activation of the c-mos oncogene in a mouse plasmacytoma by insertion of an endogenous intracisternal A-particle genome. Canaani, E., Dreazen, O., Klar, A., Rechavi, G., Ram, D., Cohen, J.B., Givol, D. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  4. Expression of the intracisternal A-particle is elevated during differentiation of embryonal carcinoma cells. Howe, C.C., Overton, G.C. Mol. Cell. Biol. (1986) [Pubmed]
  5. Identification of autonomous IAP LTR retrotransposons mobile in mammalian cells. Dewannieux, M., Dupressoir, A., Harper, F., Pierron, G., Heidmann, T. Nat. Genet. (2004) [Pubmed]
  6. Role of the p53-homologue p73 in E2F1-induced apoptosis. Stiewe, T., Pützer, B.M. Nat. Genet. (2000) [Pubmed]
  7. Neomorphic agouti mutations in obese yellow mice. Duhl, D.M., Vrieling, H., Miller, K.A., Wolff, G.L., Barsh, G.S. Nat. Genet. (1994) [Pubmed]
  8. Selective expression of intracisternal A-particle genes in established mouse plasmacytomas. Lueders, K.K., Fewell, J.W., Morozov, V.E., Kuff, E.L. Mol. Cell. Biol. (1993) [Pubmed]
  9. Insertion of an intracisternal A particle within the 5'-regulatory region of a gene encoding folate-binding protein in L1210 leukemia cells in response to low folate selection. Association with increased protein expression. Brigle, K.E., Westin, E.H., Houghton, M.T., Goldman, I.D. J. Biol. Chem. (1992) [Pubmed]
  10. Transfer of murine intracisternal A particle phenotype in chloramphenicol-resistant cytoplasts. Malech, H.L., Wivel, N.A. Cell (1976) [Pubmed]
  11. Homology between an endogenous viral LTR and sequences inserted in an activated cellular oncogene. Kuff, E.L., Feenstra, A., Lueders, K., Rechavi, G., Givol, D., Canaani, E. Nature (1983) [Pubmed]
  12. DNA damage enables p73. White, E., Prives, C. Nature (1999) [Pubmed]
  13. Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Agami, R., Blandino, G., Oren, M., Shaul, Y. Nature (1999) [Pubmed]
  14. The expression of intracisternal A particle genes in the preimplantation mouse embryo. Poznanski, A.A., Calarco, P.G. Dev. Biol. (1991) [Pubmed]
  15. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Gong, J.G., Costanzo, A., Yang, H.Q., Melino, G., Kaelin, W.G., Levrero, M., Wang, J.Y. Nature (1999) [Pubmed]
  16. DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma. Blankenstein, T., Qin, Z.H., Li, W.Q., Diamantstein, T. J. Exp. Med. (1990) [Pubmed]
  17. Glucose induces intracisternal type A retroviral gene transcription and translation in pancreatic beta cells. Leiter, E.H., Fewell, J.W., Kuff, E.L. J. Exp. Med. (1986) [Pubmed]
  18. The mouse intracisternal A particle-promoted placental gene retrotransposition is mouse-strain-specific. Chang-Yeh, A., Mold, D.E., Brilliant, M.H., Huang, R.C. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  19. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Yuan, Z.M., Shioya, H., Ishiko, T., Sun, X., Gu, J., Huang, Y.Y., Lu, H., Kharbanda, S., Weichselbaum, R., Kufe, D. Nature (1999) [Pubmed]
  20. Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1. Asher, G., Lotem, J., Sachs, L., Kahana, C., Shaul, Y. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  21. Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl. Truong, T., Sun, G., Doorly, M., Wang, J.Y., Schwartz, M.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  22. ras oncogene activates the intracisternal A particle long terminal repeat promoter through a c-AMP response element. Galien, R., Mercier, G., Garcette, M., Emanoil-Ravier, R. Oncogene (1991) [Pubmed]
  23. Murine interleukin 2 receptor beta chain: dysregulated gene expression in lymphoma line EL-4 caused by a promoter insertion. Kono, T., Doi, T., Yamada, G., Hatakeyama, M., Minamoto, S., Tsudo, M., Miyasaka, M., Miyata, T., Taniguchi, T. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  24. Shared role for differentially methylated domains of imprinted genes. Reinhart, B., Eljanne, M., Chaillet, J.R. Mol. Cell. Biol. (2002) [Pubmed]
  25. Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co-inducibility during iron overload. Ilyin, G., Courselaud, B., Troadec, M.B., Pigeon, C., Alizadeh, M., Leroyer, P., Brissot, P., Loréal, O. FEBS Lett. (2003) [Pubmed]
  26. DNA rearrangement of a homeobox gene in myeloid leukaemic cells. Blatt, C., Aberdam, D., Schwartz, R., Sachs, L. EMBO J. (1988) [Pubmed]
  27. Inherited somatic mosaicism caused by an intracisternal A particle insertion in the mouse tyrosinase gene. Wu, M., Rinchik, E.M., Wilkinson, E., Johnson, D.K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  28. Sequence organization of cloned intracisternal A particle genes. Ono, M., Cole, M.D., White, A.T., Huang, R.C. Cell (1980) [Pubmed]
  29. Immunoprecipitation of intracisternal A-particle-associated antigens from preimplantation mouse embryos. Huang, T.T., Calarco, P.G. J. Natl. Cancer Inst. (1981) [Pubmed]
  30. The mouse pale ear (ep) mutation is the homologue of human Hermansky-Pudlak syndrome. Gardner, J.M., Wildenberg, S.C., Keiper, N.M., Novak, E.K., Rusiniak, M.E., Swank, R.T., Puri, N., Finger, J.N., Hagiwara, N., Lehman, A.L., Gales, T.L., Bayer, M.E., King, R.A., Brilliant, M.H. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  31. Intracisternal A-particle genes as movable elements in the mouse genome. Kuff, E.L., Feenstra, A., Lueders, K., Smith, L., Hawley, R., Hozumi, N., Shulman, M. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
WikiGenes - Universities