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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Inhibition of basic calcium phosphate crystal-induced mitogenesis by phosphocitrate.

Basic calcium phosphate crystals control the traverse of cells from the Go/G1 to S-phase of the cell cycle and initiate proliferation by rendering fibroblasts competent to respond to insulin-like growth factors in plasma. Simultaneous addition of phosphocitrate [a powerful inhibitor of hydroxyapatite crystallization] to cells exposed to basic calcium phosphate crystals caused a dose-dependent inhibition of crystal-induced DNA synthesis and c-fos transcription. This inhibition was specific for crystal-induced mitogenesis, since similar concentrations of phosphocitrate had no effects on either PDGF or 10% calf serum- induced thymidine incorporation and c-fos transcription.[1]


  1. Inhibition of basic calcium phosphate crystal-induced mitogenesis by phosphocitrate. Cheung, H.S., Sallis, J.D., Mitchell, P.G., Struve, J.A. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
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