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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

A self-splicing group I intron in the DNA polymerase gene of Bacillus subtilis bacteriophage SPO1.

We report a self-splicing intron in bacteriophage SPO1, whose host is the gram-positive Bacillus subtilis. The intron contains all the conserved features of primary sequence and secondary structure previously described for the group IA introns of eukaryotic organelles and the gram-negative bacteriophage T4. The SPO1 intron contains an open reading frame of 522 nucleotides. As in the T4 introns, this open reading frame begins in a region that is looped out of the secondary structure, but ends in a highly conserved region of the intron core. The exons encode SPO1 DNA polymerase, which is highly similar to E. coli DNA polymerase I. The demonstration of self-splicing introns in viruses of both gram-positive and gram-negative eubacteria lends further evidence for their early origin in evolution.[1]

References

  1. A self-splicing group I intron in the DNA polymerase gene of Bacillus subtilis bacteriophage SPO1. Goodrich-Blair, H., Scarlato, V., Gott, J.M., Xu, M.Q., Shub, D.A. Cell (1990) [Pubmed]
 
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