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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The luteinizing hormone-releasing hormone pulse generator in men: abnormalities and clinical management.

Most men with hypogonadotropic eunuchoidism have absent luteinizing hormone and presumably absent luteinizing hormone-releasing hormone pulses. Pulsatile luteinizing hormone-releasing hormone therapy is effective in restoring normal gonadotropin secretion and testicular function and inducing fertility in men with hypogonadotropic eunuchoidism. Furthermore, pulsatile (versus continuous) luteinizing hormone-releasing stimulation of the pituitary gland is an absolute requirement for normal gonadotropin secretion. Men with idiopathic oligoazoospermia and selective elevation of follicle-stimulating hormone levels have slow luteinizing hormone and presumably luteinizing hormone-releasing pulse frequency. In these men, pulsatile luteinizing hormone--releasing treatment is effective in decreasing serum follicle-stimulating hormone levels, but it is unclear whether spermatogenesis and fertility are improved.[1]

References

  1. The luteinizing hormone-releasing hormone pulse generator in men: abnormalities and clinical management. Matsumoto, A.M., Gross, K.M., Sheckter, C.B., Bremner, W.J. Am. J. Obstet. Gynecol. (1990) [Pubmed]
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