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Saraste, M. et al.

The P-loop--a common motif in ATP- and GTP-binding proteins.

Many ATP- and GTP-binding proteins have a phosphate-binding loop (P-loop), the primary structure of which typically consists of a glycine-rich sequence followed by a conserved lysine and a serine or threonine. The three-dimensional structures of several ATP- and GTP-binding proteins containing P-loops have now been solved. In this review current knowledge of P-loops is discussed with the additional aim of illustrating the fascinating relationship between protein sequence, structure and function.[1]

References

The P-loop--a common motif in ATP- and GTP-binding proteins. Saraste, M., Sibbald, P.R., Wittinghofer, A. Trends Biochem. Sci. (1990) [Pubmed]

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