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Ferrero, S. et al.

Simone Ferrero, Daniela Tramalloni, Pier Luigi Venturini, Valentino Remorgida,

Vaginal danazol for women with rectovaginal endometriosis and pain symptoms persisting after insertion of a levonorgestrel-releasing intrauterine device.

OBJECTIVE: To evaluate the effectiveness of treatment with vaginal danazol in improving the pain symptoms caused by rectovaginal endometriosis that persist after insertion of a levonorgestrel-releasing intrauterine device (LNG-IUD). METHODS: This pilot observational study included 15 women with rectovaginal endometriosis and pain symptoms persisting after LNG-IUD insertion. Vaginal danazol (100mg per day) was self-administered for 6months. The intensity of pain symptoms and the volume of rectovaginal endometriotic nodules were evaluated. RESULTS: Twelve women were satisfied or very satisfied with the treatment. After treatment with vaginal danazol for 3months, there was a significant decrease in the intensity of pain symptoms compared with their intensity before the administration of danazol. The intensity of pain symptoms decreased further at 6-month follow-up. The volume of the rectovaginal nodules decreased after treatment with vaginal danazol for 6months (1.7±0.8cm(3)) compared with the baseline volume (2.3±0.9cm(3); P<0.001). Adverse effects of the treatment were minimal and well tolerated. CONCLUSION: Although a placebo effect cannot be excluded, the results indicate that vaginal danazol decreases the severity of endometriosis-related pain symptoms after LNG-IUD insertion.[1]

References

Vaginal danazol for women with rectovaginal endometriosis and pain symptoms persisting after insertion of a levonorgestrel-releasing intrauterine device. Ferrero, S., Tramalloni, D., Venturini, P.L., Remorgida, V. Int. J. Gynaecol. Obstet (2011) [Pubmed]

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