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Disease relevance of Endometriosis


Psychiatry related information on Endometriosis

  • In women with endometriosis, monthly injections of depot goserelin were effective in achieving resolution of endometriotic implants and in improving pelvic symptoms, including pain and dyspareunia [5].

High impact information on Endometriosis


Chemical compound and disease context of Endometriosis


Biological context of Endometriosis


Anatomical context of Endometriosis


Gene context of Endometriosis


Analytical, diagnostic and therapeutic context of Endometriosis


  1. Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis. Chwalisz, K., Perez, M.C., Demanno, D., Winkel, C., Schubert, G., Elger, W. Endocr. Rev. (2005) [Pubmed]
  2. Tumor-associated glycoprotein (TAG-72) in endometriotic implants. Lessey, B.A., Pindzola, J.A. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  3. Long-term progestin treatment inhibits RANTES (regulated on activation, normal T cell expressed and secreted) gene expression in human endometrial stromal cells. Zhao, D., Lebovic, D.I., Taylor, R.N. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  4. Endometriosis-specific genes identified by real-time reverse transcription-polymerase chain reaction expression profiling of endometriosis versus autologous uterine endometrium. Hu, W.P., Tay, S.K., Zhao, Y. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  5. Goserelin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in benign gynaecological disorders. Perry, C.M., Brogden, R.N. Drugs (1996) [Pubmed]
  6. Parathyroid hormone for the prevention of bone loss induced by estrogen deficiency. Finkelstein, J.S., Klibanski, A., Schaefer, E.H., Hornstein, M.D., Schiff, I., Neer, R.M. N. Engl. J. Med. (1994) [Pubmed]
  7. Dioxin tied to endometriosis. Gibbons, A. Science (1993) [Pubmed]
  8. Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Kelly, M.A., Rubinstein, M., Asa, S.L., Zhang, G., Saez, C., Bunzow, J.R., Allen, R.G., Hnasko, R., Ben-Jonathan, N., Grandy, D.K., Low, M.J. Neuron (1997) [Pubmed]
  9. Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. McLaren, J., Prentice, A., Charnock-Jones, D.S., Millican, S.A., Müller, K.H., Sharkey, A.M., Smith, S.K. J. Clin. Invest. (1996) [Pubmed]
  10. Prevention of estrogen deficiency-related bone loss with human parathyroid hormone-(1-34): a randomized controlled trial. Finkelstein, J.S., Klibanski, A., Arnold, A.L., Toth, T.L., Hornstein, M.D., Neer, R.M. JAMA (1998) [Pubmed]
  11. Endometriosis and clomiphene citrate. Svigos, J.M. Lancet (1990) [Pubmed]
  12. Adenomyosis--a result of disordered stromal differentiation. Parrott, E., Butterworth, M., Green, A., White, I.N., Greaves, P. Am. J. Pathol. (2001) [Pubmed]
  13. Antiprogestin and/or gonadotropin-releasing hormone agonist for endometriosis treatment and bone maintenance: a 1-year primate study. Grow, D.R., Williams, R.F., Hsiu, J.G., Hodgen, G.D. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  14. Deficient 17beta-hydroxysteroid dehydrogenase type 2 expression in endometriosis: failure to metabolize 17beta-estradiol. Zeitoun, K., Takayama, K., Sasano, H., Suzuki, T., Moghrabi, N., Andersson, S., Johns, A., Meng, L., Putman, M., Carr, B., Bulun, S.E. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  15. Effect of soy isoflavones on endometriosis: interaction with estrogen receptor 2 gene polymorphism. Tsuchiya, M., Miura, T., Hanaoka, T., Iwasaki, M., Sasaki, H., Tanaka, T., Nakao, H., Katoh, T., Ikenoue, T., Kabuto, M., Tsugane, S. Epidemiology (2007) [Pubmed]
  16. Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis. Burney, R.O., Talbi, S., Hamilton, A.E., Vo, K.C., Nyegaard, M., Nezhat, C.R., Lessey, B.A., Giudice, L.C. Endocrinology (2007) [Pubmed]
  17. 2-methoxyestradiol inhibits hypoxia-inducible factor-1{alpha} and suppresses growth of lesions in a mouse model of endometriosis. Becker, C.M., Rohwer, N., Funakoshi, T., Cramer, T., Bernhardt, W., Birsner, A., Folkman, J., D'Amato, R.J. Am. J. Pathol. (2008) [Pubmed]
  18. Regulation of interleukin-8 expression in human endometrial endothelial cells: a potential mechanism for the pathogenesis of endometriosis. Luk, J., Seval, Y., Kayisli, U.A., Ulukus, M., Ulukus, C.E., Arici, A. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  19. Regulation of fas ligand expression by IL-8 in human endometrium. Selam, B., Kayisli, U.A., Garcia-Velasco, J.A., Akbas, G.E., Arici, A. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  20. EMX2 gene expression in the female reproductive tract and aberrant expression in the endometrium of patients with endometriosis. Daftary, G.S., Taylor, H.S. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  21. Gonadotropin-releasing hormone agonist suppresses ovulation, menses, and endometriosis in monkeys: an individualized, intermittent regimen. Werlin, L.B., Hodgen, G.D. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  22. Increases in bone mineral density after discontinuation of daily human parathyroid hormone and gonadotropin-releasing hormone analog administration in women with endometriosis. Finkelstein, J.S., Arnold, A.L. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  23. Endometriosis and ovulatory disorder: reduced fertilisation in vitro compared with tubal and unexplained infertility. Wardle, P.G., Mitchell, J.D., McLaughlin, E.A., Ray, B.D., McDermott, A., Hull, M.G. Lancet (1985) [Pubmed]
  24. Nonmalignant epithelial cells, potentially invasive in human endometriosis, lack the tumor suppressor molecule E-cadherin. Gaetje, R., Kotzian, S., Herrmann, G., Baumann, R., Starzinski-Powitz, A. Am. J. Pathol. (1997) [Pubmed]
  25. Suppression of matrix metalloproteinase-9 by prostaglandin E(2) in peritoneal macrophage is associated with severity of endometriosis. Wu, M.H., Shoji, Y., Wu, M.C., Chuang, P.C., Lin, C.C., Huang, M.F., Tsai, S.J. Am. J. Pathol. (2005) [Pubmed]
  26. Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells. Bharti, S., Handrow-Metzmacher, H., Zickenheiner, S., Zeitvogel, A., Baumann, R., Starzinski-Powitz, A. Mol. Biol. Cell (2004) [Pubmed]
  27. Down-regulation of interleukin-1 receptor type 1 expression causes the dysregulated expression of CXC chemokines in endometriotic stromal cells: a possible mechanism for the altered immunological functions in endometriosis. Nishida, M., Nasu, K., Fukuda, J., Kawano, Y., Narahara, H., Miyakawa, I. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  28. Possible involvement of hMLH1, p16(INK4a) and PTEN in the malignant transformation of endometriosis. Martini, M., Ciccarone, M., Garganese, G., Maggiore, C., Evangelista, A., Rahimi, S., Zannoni, G., Vittori, G., Larocca, L.M. Int. J. Cancer (2002) [Pubmed]
  29. Inflammatory status influences aromatase and steroid receptor expression in endometriosis. Bukulmez, O., Hardy, D.B., Carr, B.R., Word, R.A., Mendelson, C.R. Endocrinology (2008) [Pubmed]
  30. Shift work, hCLOCK T3111C polymorphism, and endometriosis risk. Marino, J.L., Holt, V.L., Chen, C., Davis, S. Epidemiology (2008) [Pubmed]
  31. MicroRNA-regulated pathways associated with endometriosis. Ohlsson Teague, E.M., Van der Hoek, K.H., Van der Hoek, M.B., Perry, N., Wagaarachchi, P., Robertson, S.A., Print, C.G., Hull, L.M. Mol. Endocrinol. (2009) [Pubmed]
  32. Identification of an invasive, N-cadherin-expressing epithelial cell type in endometriosis using a new cell culture model. Zeitvogel, A., Baumann, R., Starzinski-Powitz, A. Am. J. Pathol. (2001) [Pubmed]
  33. Therapeutic effect of angiostatin gene transfer in a murine model of endometriosis. Dabrosin, C., Gyorffy, S., Margetts, P., Ross, C., Gauldie, J. Am. J. Pathol. (2002) [Pubmed]
  34. Cortical remodeling following suppression of endogenous estrogen with analogs of gonadotrophin releasing hormone. Bell, K.L., Loveridge, N., Lindsay, P.C., Lunt, M., Garrahan, N., Compston, J.E., Reeve, J. J. Bone Miner. Res. (1997) [Pubmed]
  35. Spatially heterogeneous expression of aromatase P450 through promoter II is closely correlated with the level of steroidogenic factor-1 transcript in endometrioma tissues. Yang, H.J., Shozu, M., Murakami, K., Sumitani, H., Segawa, T., Kasai, T., Inoue, M. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  36. Aberrant integrin expression in the endometrium of women with endometriosis. Lessey, B.A., Castelbaum, A.J., Sawin, S.W., Buck, C.A., Schinnar, R., Bilker, W., Strom, B.L. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
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