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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

S100 protein and Down syndrome.

S100 protein is a low molecular weight calcium-binding protein widely distributed in the central nervous system of vertebrates. Recent evidence suggests that S100 protein may play a role in the regulation of glial proliferation and neuronal differentiation. The gene for S100 protein has been mapped to the 21q22 region, a chromosomal locus whose duplication has been implicated in the generation of Down Syndrome (DS). This raises the possibility that abnormalities in S100 protein gene dosage at a critical period during development may be responsible for some of the neurologic abnormalities associated with DS.[1]


  1. S100 protein and Down syndrome. Marks, A., Allore, R. Bioessays (1990) [Pubmed]
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